Evidence map›Paper›PMID 38674868›Full record

ArticleNutrients2024

Vitamin A Status Modulates Epithelial Mesenchymal Transition in the Lung: The Role of Furin.

M Teresa Cabezuelo, Luis Torres, Elena Ortiz-Zapater, Gerardo López-Rodas, M Pilar Marín, Joaquín Timoneda, Juan R Viña, Rosa Zaragozá, Teresa Barber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

M Teresa CabezueloDepartment of Physiology, University of Valencia, 46010 Valencia, Spain.
Luis TorresDepartment of Biochemistry and Molecular Biology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.
Elena Ortiz-ZapaterDepartment of Biochemistry and Molecular Biology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0002-7437-4772
Gerardo López-RodasDepartment of Biochemistry and Molecular Biology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0001-8367-653X
M Pilar MarínMicroscopy Unit IIS La Fe Valencia, 46009 Valencia, Spain.
Joaquín TimonedaDepartment of Biochemistry and Molecular Biology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.
Juan R ViñaDepartment of Biochemistry and Molecular Biology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.
Rosa ZaragozáDepartment of Human Anatomy and Embryology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.
Teresa BarberDepartment of Biochemistry and Molecular Biology-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain.
Universitat de València · ESInstituto de Investigación Sanitaria La Fe · ES

Funding

Generalitat Valenciana CIPROM/2021/051
6 · The paper itself

Abstract

Vitamin A deficiency (VAD) induced TGF-β hyperactivation and reduced expression of cell adhesion proteins in the lung, suggesting that the disruption of retinoic acid (RA) signaling leads to epithelial-mesenchymal transition (EMT). To elucidate the role of lung vitamin A status in EMT, several EMT markers and the expression of the proprotein convertase furin, which activates TGF-β, were analyzed in two experimental models. Our in vivo model included control rats, VAD rats, and both control rats and VAD rats, treated with RA. For the in vitro studies, human bronchoalveolar epithelial cells treated with RA were used. Our data show that EMT and furin are induced in VAD rats. Furthermore, furin expression continues to increase much more markedly after treatment of VAD rats with RA. In control rats and cell lines, an acute RA treatment induced a significant increase in furin expression, concomitant with changes in EMT markers. A ChIP assay demonstrated that RA directly regulates furin transcription. These results emphasize the importance of maintaining vitamin A levels within the physiological range since both levels below and above this range can cause adverse effects that, paradoxically, could be similar. The role of furin in EMT is discussed.

Indexed as

Epithelial-Mesenchymal TransitionFurinLungVitamin AVitamin A DeficiencyAnimalsCell LineEpithelial CellsHumansMaleRatsRats, WistarSignal TransductionTransforming Growth Factor betaTretinoinFurinTransforming Growth Factor betaTretinoinVitamin AE-cadherinepithelial–mesenchymal transitionextracellular matrixfurinlungN-cadherinpulmonary diseaseretinoic acidretinolvitamin A deficiency

Identifiers

PMID38674868
PMCPMC11053499
OpenAlexW4394820536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.