Evidence map›Paper›PMID 38674858›Full record

ArticleNutrients2024

Interpreting the Mechanism of Active Ingredients in Polygonati Rhizoma in Treating Depression by Combining Systemic Pharmacology and In Vitro Experiments.

Xin Wei, Dan Wang, Jiajia Liu, Qizhi Zhu, Ziming Xu, Jinzhe Niu, Weiping Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Xin WeiInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
Dan WangDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Jiajia LiuDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Qizhi ZhuInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
Ziming XuDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Jinzhe NiuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China.
Weiping XuInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
University of Science and Technology of China · CNHefei Institutes of Physical Science · CNHefei University of Technology · CNInstitute of Intelligent Machines · CN

Funding

National Natural Science Foundation of China 52072360
6 · The paper itself

Abstract

Polygonati Rhizoma (PR) has certain neuroprotective effects as a homology of medicine and food. In this study, systematic pharmacology, molecular docking, and in vitro experiments were integrated to verify the antidepressant active ingredients in PR and their mechanisms. A total of seven compounds in PR were found to be associated with 45 targets of depression. Preliminarily, DFV docking with cyclooxygenase 2 (COX2) showed good affinity. In vitro, DFV inhibited lipopolysaccharide (LPS)-induced inflammation of BV-2 cells, reversed amoeba-like morphological changes, and increased mitochondrial membrane potential. DFV reversed the malondialdehyde (MDA) overexpression and superoxide dismutase (SOD) expression inhibition in LPS-induced BV-2 cells and decreased interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-6 mRNA expression levels in a dose-dependent manner. DFV inhibited both mRNA and protein expression levels of COX2 induced by LPS, and the activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and caspase1 was suppressed, thus exerting an antidepressant effect. This study proves that DFV may be an important component basis for PR to play an antidepressant role.

Indexed as

Antidepressive AgentsCyclooxygenase 2DepressionLipopolysaccharidesMolecular Docking SimulationPolygonatumRhizomeAnimalsCell LineDrugs, Chinese HerbalMalondialdehydeMembrane Potential, MitochondrialMiceNLR Family, Pyrin Domain-Containing 3 ProteinSuperoxide DismutaseAntidepressive AgentsCyclooxygenase 2Drugs, Chinese HerbalLipopolysaccharidesMalondialdehydeNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePtgs2 protein, mouseSuperoxide DismutasedepressionDFVinflammationPolygonati Rhizomasystemic pharmacology

Identifiers

PMID38674858
PMCPMC11054788
OpenAlexW4394815157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.