Evidence map›Paper›PMID 38674835›Full record

ArticleNutrients2024

S/O/W Emulsion with CAPE Ameliorates DSS-Induced Colitis by Regulating NF-κB Pathway, Gut Microbiota and Fecal Metabolome in C57BL/6 Mice.

Xuelin Wei, Juan Dai, Ruijia Liu, Guochao Wan, Shiyu Gu, Yuwei Du, Xinyue Yang, Lijun Wang, Yukun Huang, Pengfei Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Xuelin WeiSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Juan DaiSchool of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China.
Ruijia LiuSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Guochao WanSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Shiyu GuSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Yuwei DuSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.ORCID 0000-0002-5781-6268
Xinyue YangSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Lijun WangSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.ORCID 0000-0002-5260-2092
Yukun HuangSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Pengfei ChenSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Xianggui ChenSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Xiao YangSchool of Food and Bioengineering, Xihua University, Chengdu 610039, China.ORCID 0000-0001-7968-7260
Qin WangDepartment of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-7496-3921
Xihua University · CNChengdu Medical College · CNUniversity of Maryland, College Park · US

Funding

National Natural Science Foundation of China 3197160117Science and Technology Department of Sichuan Province 2022JDTD0028Science and Technology Department of Sichuan Province 2022YFN0016
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) has attracted much attention worldwide due to its prevalence. In this study, the effect of a solid-in-oil-in-water (S/O/W) emulsion with Caffeic acid phenethyl ester (CAPE, a polyphenolic active ingredient in propolis) on dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice was evaluated. The results showed that CAPE-emulsion could significantly alleviate DSS-induced colitis through its effects on colon length, reduction in the disease activity index (DAI), and colon histopathology. The results of ELISA and Western blot analysis showed that CAPE-emulsion can down-regulate the excessive inflammatory cytokines in colon tissue and inhibit the expression of p65 in the NF-κB pathway. Furthermore, CAPE-emulsion promoted short-chain fatty acids production in DSS-induced colitis mice. High-throughput sequencing results revealed that CAPE-emulsion regulates the imbalance of gut microbiota by enhancing diversity, restoring the abundance of beneficial bacteria (such as

Indexed as

Caffeic AcidsColitisEmulsionsAnimalsColonCytokinesDextran SulfateDisease Models, AnimalFecesGastrointestinal MicrobiomeMaleMetabolomeMiceMice, Inbred C57BLNF-kappa BPhenylethyl Alcoholcaffeic acid phenethyl esterCaffeic AcidsCytokinesDextran SulfateEmulsionsNF-kappa BPhenylethyl AlcoholcolitisCPAEfecal metabolismgut microbiotaS/O/W emulsion

Identifiers

PMID38674835
PMCPMC11054280
OpenAlexW4394749976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.