Evidence map›Paper›PMID 38674812›Full record

ArticleNutrients2024

Ser9p-GSK3β Modulation Contributes to the Protective Effects of Vitamin C in Neuroinflammation.

Melania Ruggiero, Antonia Cianciulli, Rosa Calvello, Chiara Porro, Francesco De Nuccio, Marianna Kashyrina, Alessandro Miraglia, Dario Domenico Lofrumento, Maria Antonietta Panaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Melania RuggieroDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.
Antonia CianciulliDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.ORCID 0000-0002-9851-3124
Rosa CalvelloDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.
Chiara PorroDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy.ORCID 0000-0002-7526-6968
Francesco De NuccioDepartment of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, 73100 Lecce, Italy.ORCID 0000-0003-2041-0149
Marianna KashyrinaDepartment of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, 73100 Lecce, Italy.ORCID 0000-0001-7266-6387
Alessandro MiragliaDepartment of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, 73100 Lecce, Italy.ORCID 0000-0003-0874-4429
Dario Domenico LofrumentoDepartment of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, 73100 Lecce, Italy.ORCID 0000-0002-0106-3615
Maria Antonietta PanaroDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.ORCID 0000-0001-5457-1069
University of Bari Aldo Moro · ITUniversity of Salento · ITUniversity of Foggia · IT

Funding

European Union Next Generation EU (PE00000006 "MNESYS")
6 · The paper itself

Abstract

backgroundThe prolonged activation of microglia and excessive production of pro-inflammatory cytokines can lead to chronic neuroinflammation, which is an important pathological feature of Parkinson's disease (PD). We have previously reported the protective effect of Vitamin C (Vit C) on a mouse model of PD. However, its effect on microglial functions in neuroinflammation remains to be clarified. Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase having a role in driving inflammatory responses, making GSK3β inhibitors a promising target for anti-inflammatory research.

methodsIn this study, we investigated the possible involvement of GSK3β in Vit C neuroprotective effects by using a well-known 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of PD and a cellular model of neuroinflammation, represented by Lipopolysaccharide (LPS)-activated BV-2 microglial cells.

resultsWe demonstrated the ability of Vit C to decrease the expression of different mediators involved in the inflammatory responses, such as TLR4, p-IKBα, and the phosphorylated forms of p38 and AKT. In addition, we demonstrated for the first time that Vit C promotes the GSK3β inhibition by stimulating its phosphorylation at Ser9.

conclusionThis study evidenced that Vit C exerts an anti-inflammatory function in microglia, promoting the upregulation of the M2 phenotype through the activation of the Wnt/β-catenin signaling pathway.

Indexed as

Anti-Inflammatory AgentsAscorbic AcidNeuroinflammatory DiseasesNeuroprotective AgentsAnimalsCell LineDisease Models, AnimalGlycogen Synthase Kinase 3 betaLipopolysaccharidesMaleMiceMice, Inbred C57BLMicrogliaParkinson DiseasePhosphorylationSerineAnti-Inflammatory AgentsAscorbic AcidGlycogen Synthase Kinase 3 betaGsk3b protein, mouseLipopolysaccharidesNeuroprotective AgentsSerineGSK3βmicroglianeuroinflammationneuroprotectionVitamin CWnt/β-catenin signaling pathway

Identifiers

PMID38674812
PMCPMC11053771
OpenAlexW4394676266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.