Evidence map›Paper›PMID 38674674›Full record

ArticleMicroorganisms2024

Validation of a Human Challenge Model Using an LT-Expressing Enterotoxigenic

Kawsar R Talaat, Chad K Porter, Subhra Chakraborty, Brittany L Feijoo, Jessica Brubaker, Brittany M Adjoodani, Barbara DeNearing, Michael G Prouty, Steven T Poole, A Louis Bourgeois and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  2. Article
  3. Building a Broader Understanding of EnterotoxigenicOpen forum infectious diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Kawsar R TalaatDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-4899-6260
Chad K PorterNaval Medical Research Command, Silver Spring, MD 20910, USA.
Subhra ChakrabortyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-6446-0255
Brittany L FeijooDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Jessica BrubakerDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Brittany M AdjoodaniDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Barbara DeNearingDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Michael G ProutyNaval Medical Research Command, Silver Spring, MD 20910, USA.
Steven T PooleNaval Medical Research Command, Silver Spring, MD 20910, USA.
A Louis BourgeoisDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Madison BillingsleyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
David A SackDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Susanne Eder-LingelbachValneva, Austria GmbH, 1030 Vienna, Austria.
Christian TaucherValneva, Austria GmbH, 1030 Vienna, Austria.
Johns Hopkins University · USNaval Medical Research Command · USValneva (Austria) · AT

Funding

Valneva (Austria) 127663
6 · The paper itself

Abstract

Controlled human infection models are important tools for the evaluation of vaccines against diseases where an appropriate correlate of protection has not been identified. Enterotoxigenic

Indexed as

challenge studycontrolled human infection modelenterotoxigenic E. colivaccine

Identifiers

PMID38674674
PMCPMC11051778
OpenAlexW4393899030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.