Evidence map›Paper›PMID 38674429›Full record

ArticleGenes2024

Heritability of Gene Expression Measured from Peripheral Blood in Older Adults.

Sri C Kanchibhotla, Karen A Mather, Nicola J Armstrong, Liliana G Ciobanu, Bernhard T Baune, Vibeke S Catts, Peter R Schofield, Julian N Trollor, David Ames, Perminder S Sachdev and 1 more

Open access · goldAbstract readTwin Study
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sri C KanchibhotlaCentre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Karen A MatherCentre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Nicola J ArmstrongDepartment of Mathematics and Statistics, Curtin University, Perth, WA 6845, Australia.ORCID 0000-0002-4477-293X
Liliana G CiobanuDiscipline of Psychiatry, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia.
Bernhard T BauneDiscipline of Psychiatry, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia.
Vibeke S CattsCentre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Peter R SchofieldNeuroscience Research Australia, Sydney, NSW 2031, Australia.ORCID 0000-0003-2967-9662
Julian N TrollorCentre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-7685-2977
David AmesAcademic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, Melbourne, VIC 3010, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-9595-3220
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-7114-1260
UNSW Sydney · AUThe University of Melbourne · AUCurtin University · AUThe University of Adelaide · AU

Funding

ARC Strategic Award Grant of the Ageing Well, Ageing Productively Programme ID No. 401162National Health and Medical Research Council ID 1060524National Health and Medical Research Council ID No. 1024224, 1025243, 1045325, 1085606, 1060524National Health and Medical Research Council ID No. 568969 and 1093083Twins Research Australia ID 1079102
6 · The paper itself

Abstract

The contributions of genetic variation and the environment to gene expression may change across the lifespan. However, few studies have investigated the heritability of blood gene expression in older adults. The current study therefore aimed to investigate this question in a community sample of older adults. A total of 246 adults (71 MZ and 52 DZ twins, 69.91% females; mean age-75.79 ± 5.44) were studied. Peripheral blood gene expression was assessed using Illumina microarrays. A heritability analysis was performed using structural equation modelling. There were 5269 probes (19.9%) from 4603 unique genes (23.9%) (total 26,537 probes from 19,256 genes) that were significantly heritable (mean h

Indexed as

AgingAgedAged, 80 and overFemaleGene ExpressionHumansMaleTwins, DizygoticTwins, Monozygoticgene expressionheritabilityolder adultstwins

Identifiers

PMID38674429
PMCPMC11049887
OpenAlexW4394837311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.