Evidence map›Paper›PMID 38674428›Full record

ArticleGenes2024

Identification of Key Genes and Imbalanced SNAREs Assembly in the Comorbidity of Polycystic Ovary Syndrome and Depression.

Yi Cao, Weijing Wang, Xuxia Song, Qian Wen, Jing Xie, Dongfeng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yi CaoBiomedical Center, Qingdao University, No. 308 Ningxia Road, Qingdao 266021, China.
Weijing WangDepartment of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 308 Ningxia Road, Qingdao 266021, China.
Xuxia SongBiomedical Center, Qingdao University, No. 308 Ningxia Road, Qingdao 266021, China.
Qian WenBiomedical Center, Qingdao University, No. 308 Ningxia Road, Qingdao 266021, China.
Jing XieBiomedical Center, Qingdao University, No. 308 Ningxia Road, Qingdao 266021, China.
Dongfeng ZhangDepartment of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 308 Ningxia Road, Qingdao 266021, China.ORCID 0000-0001-9308-9371
Qingdao University · CN

Funding

Shandong Province Medical and Health Technology Development Fund 202102021141
6 · The paper itself

Abstract

backgroundWomen with polycystic ovary syndrome (PCOS) have increased odds of concurrent depression, indicating that the relationship between PCOS and depression is more likely to be comorbid. However, the underlying mechanism remains unclear. Here, we aimed to use bioinformatic analysis to screen for the genetic elements shared between PCOS and depression.

methodsDifferentially expressed genes (DEGs) were screened out through GEO2R using the PCOS and depression datasets in NCBI. Protein-protein interaction (PPI) network analysis and enrichment analysis were performed to identify the potential hub genes. After verification using other PCOS and depression datasets, the associations between key gene polymorphism and comorbidity were further studied using data from the UK biobank (UKB) database.

resultsIn this study, three key genes, namely,

conclusionsOur study suggests that the

Indexed as

DepressionPolycystic Ovary SyndromeProtein Interaction MapsComorbidityComputational BiologyFemaleGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideQb-SNARE ProteinsQc-SNARE ProteinsSNARE ProteinsQb-SNARE ProteinsQc-SNARE ProteinsSNARE Proteinscomorbiditydepressionpolycystic ovary syndrome (PCOS)single nucleotide polymorphisms (SNPs)SNAREs

Identifiers

PMID38674428
PMCPMC11049873
OpenAlexW4394806082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.