Unravelling the Genetic Landscape of Hemiplegic Migraine: Exploring Innovative Strategies and Emerging Approaches.

Mohammed M Alfayyadh, Neven Maksemous, Heidi G Sutherland, Rod A Lea, Lyn R Griffiths

Open access · goldAbstract readReview

In one paragraph

Review in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed, 1 pooled it

2.7field-weighted citation impact, top 10% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

Genetic Basis of the Negative Response to the Use of Triptans for the Treatment of Migraine-A Systematic Review and Meta-Analysis.Brain and behavior · 2025
Pooled it
From Stroke Suspicion to Genetic Confirmation: Familial Hemiplegic Migraine Type 2 as a Rare Stroke Mimic With Persistent Hemiplegia.Cureus · 2025
Article
Gene-Based Burden Testing of Rare Variants in Hemiplegic Migraine: A Computational Approach to Uncover the Genetic Architecture of a Rare Brain Disorder.Genes · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mohammed M AlfayyadhCentre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.

Neven MaksemousCentre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.ORCID 0000-0002-4891-4333

Heidi G SutherlandCentre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.ORCID 0000-0002-8512-1498

Rod A LeaCentre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.

Lyn R GriffithsCentre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.ORCID 0000-0002-6774-5475

Queensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is a severe, debilitating neurovascular disorder. Hemiplegic migraine (HM) is a rare and debilitating neurological condition with a strong genetic basis. Sequencing technologies have improved the diagnosis and our understanding of the molecular pathophysiology of HM. Linkage analysis and sequencing studies in HM families have identified pathogenic variants in ion channels and related genes, including

Indexed as

Migraine with AuraCalcium ChannelsCalcium Channels, N-TypeGenetic LinkageGenetic Predisposition to DiseaseHumansMutationNAV1.1 Voltage-Gated Sodium ChannelSodium-Potassium-Exchanging ATPaseATP1A2 protein, humanCACNA1A protein, humanCalcium ChannelsCalcium Channels, N-TypeNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, humanSodium-Potassium-Exchanging ATPasebioinformaticshemiplegic migrainesequence variantswhole exome sequencing

Identifiers

PMID38674378

DOI10.3390/genes15040443

PMCPMC11049430

OpenAlexW4393357299

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.