Evidence map›Paper›PMID 38674359›Full record

ArticleGenes2024

A Case Study of a Rare Undifferentiated Spindle Cell Sarcoma of the Penis: Establishment and Characterization of Patient-Derived Models.

Ariane Cavalcante Dos Santos Sousa, Bruno Leonardo Nascimento Correa Fernandes, Jeronimo Paulo Assis da Silva, Paulo Roberto Stevanato Filho, Luiza Bitencourt de Carvalho Terci Coimbra, Adriano de Oliveira Beserra, Ana Luiza Alvarenga, Giovanna Maida, Camila Tokumoto Guimaraes, Ingrid Martinez Nakamuta and 11 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Ariane Cavalcante Dos Santos SousaClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
Bruno Leonardo Nascimento Correa FernandesSao Lucas Hospital Rede D'Or, Sergipe Emergency Hospital Oncology Service, Aracaju 49081-060, Brazil.
Jeronimo Paulo Assis da SilvaReal Institute of Oncological Surgery, Real Hospital Português, Recife 52010-075, Brazil.
Paulo Roberto Stevanato FilhoReference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.
Luiza Bitencourt de Carvalho Terci CoimbraClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.ORCID 0000-0001-7119-8681
Adriano de Oliveira BeserraClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
Ana Luiza AlvarengaClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
Giovanna MaidaClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
Camila Tokumoto GuimaraesClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
Ingrid Martinez NakamutaGraduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil.
Fabio Albuquerque MarchiCenter for Translational Research in Oncology, Cancer Institute of the State of Sao Paulo (ICESP), Clinical Hospital of the University of Sao Paulo Medical School (HCFMUSP), Sao Paulo 01246-000, Brazil.
Camila AlvesZiel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil.
Martina LichtenfelsZiel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil.
Caroline Brunetto de FariasZiel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil.
Bruna Elisa Catin KupperReference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.ORCID 0000-0003-3430-3336
Felipe D'Almeida CostaReference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.ORCID 0000-0002-6470-749X
Celso Abdon Lopes de MelloReference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.ORCID 0000-0002-8315-1562
Dirce Maria CarraroClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.
Giovana Tardin TorrezanClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.ORCID 0000-0002-8659-5329
Ademar LopesReference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.
Tiago Goss Dos SantosClinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.ORCID 0000-0001-6641-7413
AC Camargo Hospital · BRUniversidade de São Paulo · BRReal Hospital Português · BRUniversidade Federal de Sergipe · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/50943-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/25541-8National Council for Scientific and Technological Development 465682/2014-6
6 · The paper itself

Abstract

Rare sarcomas present significant treatment challenges compared to more prevalent soft tissue sarcomas due to limited treatment options and a poor understanding of their biology. This study investigates a unique case of penile sarcoma, providing a comprehensive morphological and molecular analysis. Through the creation of experimental patient-derived models-including patient-derived xenograft (PDX), 3D, and monolayer primary cultures-we successfully replicated crucial molecular traits observed in the patient's tumor, such as smooth muscle actin and CD99 expression, along with specific mutations in genes like

Indexed as

SarcomaAnimalsHumansMaleMiceMiddle AgedMutationPenile NeoplasmsTuberous Sclerosis Complex 2 ProteinTSC2 protein, humanTuberous Sclerosis Complex 2 Proteinchemosensitivityfunctional precision oncologypreclinical modelssarcomas

Identifiers

PMID38674359
PMCPMC11049969
OpenAlexW4393279144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.