Evidence map›Paper›PMID 38674128›Full record

ArticleInternational journal of molecular sciences2024

Redox Homeostasis Alteration Is Restored through Melatonin Treatment in COVID-19 Patients: A Preliminary Study.

María Elena Soto, Israel Pérez-Torres, Linaloe Manzano-Pech, Adrían Palacios-Chavarría, Rafael Ricardo Valdez-Vázquez, Verónica Guarner-Lans, Elizabeth Soria-Castro, Eulises Díaz-Díaz, Vicente Castrejón-Tellez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Elena SotoResearch Direction, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0003-1332-2888
Israel Pérez-TorresDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0000-0001-6510-2954
Linaloe Manzano-PechDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Adrían Palacios-ChavarríaCritical Care Units, Temporal COVID-19 Unit, Citibanamex Center, Mexico City 11200, Mexico.
Rafael Ricardo Valdez-VázquezCritical Care Units, Temporal COVID-19 Unit, Citibanamex Center, Mexico City 11200, Mexico.
Verónica Guarner-LansDepartment of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0002-2655-7590
Elizabeth Soria-CastroDepartment of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Eulises Díaz-DíazDepartment of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City 14000, Mexico.
Vicente Castrejón-TellezDepartment of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0002-8518-6961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type II pneumocytes are the target of the SARS-CoV-2 virus, which alters their redox homeostasis to increase reactive oxygen species (ROS). Melatonin (MT) has antioxidant proprieties and protects mitochondrial function. In this study, we evaluated whether treatment with MT compensated for the redox homeostasis alteration in serum from COVID-19 patients. We determined oxidative stress (OS) markers such as carbonyls, glutathione (GSH), total antioxidant capacity (TAC), thiols, nitrites (NO

Indexed as

AntioxidantsCOVID-19COVID-19 Drug TreatmentHomeostasisMelatoninOxidation-ReductionOxidative StressSARS-CoV-2AdultAgedFemaleGlutathioneHumansLipid PeroxidationMaleMiddle AgedAntioxidantsGlutathioneMelatoninReactive Oxygen Speciesantioxidant enzymesCOVID-19melatoninoxidative stressredox homeostasisSARS-CoV-2

Identifiers

PMID38674128
PMCPMC11050031

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.