Evidence map›Paper›PMID 38674120›Full record

ArticleInternational journal of molecular sciences2024

Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the Göttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome.

Timothy Horseman, W Bradley Rittase, John E Slaven, Dmitry T Bradfield, Andrew M Frank, Joseph A Anderson, Evelyn C Hays, Andrew C Ott, Anjali E Thomas, Alison R Huppmann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Timothy HorsemanDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
W Bradley RittaseDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
John E SlavenDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Dmitry T BradfieldDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Andrew M FrankDepartment of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Joseph A AndersonComparative Pathology Division, Department of Laboratory Animal Resources, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Evelyn C HaysDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Andrew C OttDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Anjali E ThomasDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Alison R HuppmannDepartment of Biomedical Sciences, University of South Carolina School of Medicine, Greenville, SC 29605, USA.
Sang-Ho LeePathology Department, Research Services, Naval Medical Research Center, Silver Spring, MD 20910, USA.
David M BurmeisterDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-1256-0158
Regina M DayDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Uniformed Services University of the Health Sciences · USHenry M. Jackson Foundation · USNaval Medical Research Command · USUniversity of South Carolina · US

Funding

Defense Medical Research and Materiel Command, Radiation Health Effects Research Program, Joint Program Committee 7 numbers DM178018 and 1 I80 VP000264-01USU Startup Funding MED-11233
6 · The paper itself

Abstract

Hematopoietic acute radiation syndrome (H-ARS) involves injury to multiple organ systems following total body irradiation (TBI). Our laboratory demonstrated that captopril, an angiotensin-converting enzyme inhibitor, mitigates H-ARS in Göttingen minipigs, with improved survival and hematopoietic recovery, as well as the suppression of acute inflammation. However, the effects of captopril on the gastrointestinal (GI) system after TBI are not well known. We used a Göttingen minipig H-ARS model to investigate captopril's effects on the GI following TBI (

Indexed as

Acute Radiation SyndromeCaptoprilDisease Models, AnimalFerroptosisGastrointestinal MicrobiomeInflammationSwine, MiniatureWhole-Body IrradiationAngiotensin-Converting Enzyme InhibitorsAnimalsIntestinesMaleSwineAngiotensin-Converting Enzyme InhibitorsCaptoprilacute radiation syndromecaptoprilferroptosisgastrointestinal injuryH-ARSinflammationmicrobiomeminipigs

Identifiers

PMID38674120
PMCPMC11050692
OpenAlexW4395011247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.