ArticleInternational journal of molecular sciences2024
Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa.
Nathan Calzadilla, Dulari Jayawardena, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Abhijith Eathara, Seema Saksena, Pradeep K Dudeja, Waddah A Alrefai and 1 more
Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 1 institution in 1 country.
Nathan CalzadillaDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.
Dulari JayawardenaDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-3281-6517
Aisha QaziDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Anchal SharmaDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Kai MonganDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Shane ComiskeyDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Abhijith EatharaDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Seema SaksenaDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-2166-6317
Pradeep K DudejaDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Waddah A AlrefaiDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.
Ravinder K GillDivision of Gastroenterology & Hepatology, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-5337-2567
University of Illinois Chicago · US
Funding
Intestinal Anion Transporters: Function and RegulationR01DK054016 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 1998 to 2022
$7.0M
Transporter Trafficking Mechanisms in Infectious DiarrheaR01DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2011 to 2020
$3.0M
Intestinal 5-HT Transporter: A novel therapeutic target for GI disordersR01DK098170 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILL, RAVINDER K · 2014 to 2022
$3.0M
The roles of intestinal epithelial AhR in alcohol-induced barrier dysfunction and liver injuryF30AA030222 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CALZADILLA, NATHAN · 2022 to 2024
$96k
BCCMA: Targeting Gut-Microbiome in Veterans Deployment Related Gastrointestinal and Liver Diseases; CMA1- The Role of GWI Gut Microbiome in Susceptibility to Diarrheal DiseasesI01BX005862 · VA · JESSE BROWN VA MEDICAL CENTER · PI Pradeep K Dudeja · 2023 to 2026
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Role of intestinal serotonin transporter in post traumatic stress disorderI01BX006177 · VA · JESSE BROWN VA MEDICAL CENTER · PI GILL, RAVINDER K · 2023 to 2025
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BLR&D Research Career Scientist Award ApplicationIK6BX005242 · VA · JESSE BROWN VA MEDICAL CENTER · PI Pradeep K Dudeja · 2020 to 2026
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BLRD Research Career Scientist Award ApplicationIK6BX005243 · VA · JESSE BROWN VA MEDICAL CENTER · PI ALREFAI, WADDAH A. · 2020 to 2025
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Regulation of Intestinal Sodium Absorption in Health and DiseaseI01BX002867 · VA · JESSE BROWN VA MEDICAL CENTER · PI Seema Saksena · 2016 to 2026
–
Mechanisms of Regulation of Intestinal Cl Absorption in IBD Associated DiarrheaI01BX002011 · VA · JESSE BROWN VA MEDICAL CENTER · PI DUDEJA, PRADEEP K · 2013 to 2024
–
Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related DisordersI01BX000152 · VA · JESSE BROWN VA MEDICAL CENTER · PI Waddah A. Alrefai · 2009 to 2026
–
BLRD VA I01 BX000152BLRD VA I01 BX002011BLRD VA I01 BX002867BLRD VA I01 BX005862BLRD VA I01 BX006177BLRD VA IK6 BX005242BLRD VA IK6 BX005243NIAAA NIH HHS F30 AA030222NIDDK NIH HHS R01 DK054016NIDDK NIH HHS R01 DK092441NIDDK NIH HHS R01 DK098170NIH HHS F30AA030222NIH HHS R01 DK054016NIH HHS R01 DK092441NIH HHS R01 DK098170
6 · The paper itself
Abstract
Serotonin transporter (SERT) deficiency has been implicated in metabolic syndrome, intestinal inflammation, and microbial dysbiosis. Interestingly, changes in microbiome metabolic capacity and several alterations in host gene expression, including lipid metabolism, were previously observed in SERT
Indexed as
Gastrointestinal MicrobiomeIleumIntestinal MucosaMice, KnockoutSerotonin Plasma Membrane Transport ProteinsAnimalsLipid MetabolismMaleMetabolomeMetabolomicsMiceMice, Inbred C57BLSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouselipid metabolismmetabolic syndromemetabolomicsserotoninserotonin transporter
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa. · full record | OpenQuestion