Evidence map›Paper›PMID 38674023›Full record

ArticleInternational journal of molecular sciences2024

Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract.

Viktoriia Cherkasova, Yaroslav Ilnytskyy, Olga Kovalchuk, Igor Kovalchuk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Viktoriia CherkasovaDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Yaroslav IlnytskyyDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Olga KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Igor KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.ORCID 0000-0002-8137-6928
University of Lethbridge · CA

Funding

MITACS MITACS Accelerate IT11447NSERC RGPIN 2016-06555
6 · The paper itself

Abstract

Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop resistance to cisplatin, forcing scientists to look for alternatives or synergistic combinations with other drugs. In this work, we attempted to find a potential synergistic effect between cisplatin and cannabinoid delta-9-THC, as well as the high-THC

Indexed as

CannabisCisplatinColorectal NeoplasmsDronabinolPlant ExtractsTranscriptomeAntineoplastic AgentsApoptosisCell Line, TumorDrug Resistance, NeoplasmGene Expression ProfilingGene Expression Regulation, NeoplasticHT29 CellsHumansAntineoplastic AgentsCisplatinDronabinolPlant Extractscannabis extractcisplatincolorectal cancerdelta-9-tetrahydrocannabinol

Identifiers

PMID38674023
PMCPMC11050262
OpenAlexW4394920604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.