ArticleInternational journal of molecular sciences2024
Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria.
Carla Di Chio, Josè Starvaggi, Noemi Totaro, Santo Previti, Benito Natale, Sandro Cosconati, Marta Bogacz, Tanja Schirmeister, Jenny Legac, Philip J Rosenthal and 2 more
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors at 5 institutions in 3 countries.
Carla Di ChioDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.
Josè StarvaggiDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.
Noemi TotaroDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.
Santo PrevitiDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.ORCID 0000-0001-8473-3321 Benito NataleDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0009-0002-2065-2535 Sandro CosconatiDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0002-8900-0968 Marta BogaczInstitute of Organic Chemistry & Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstraße, 10, DE 07743 Jena, Germany.ORCID 0009-0004-5107-4904 Tanja SchirmeisterInstitute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, DE 55128 Mainz, Germany.
Jenny LegacDepartment of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, CA 94110, USA.
Philip J RosenthalDepartment of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, CA 94110, USA.
Maria ZappalàDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.ORCID 0000-0002-8942-797X Roberta EttariDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.ORCID 0000-0001-9020-2068 University of Messina · ITSan Francisco General Hospital · USUniversity of Campania "Luigi Vanvitelli" · ITFriedrich Schiller University Jena · DEJohannes Gutenberg University Mainz · DE
Funding
PRIN2022_PNRR P2022KCW3L
6 · The paper itselfAbstract
In recent decades, neglected tropical diseases and poverty-related diseases have become a serious health problem worldwide. Among these pathologies, human African trypanosomiasis, and malaria present therapeutic problems due to the onset of resistance, toxicity problems and the limited spectrum of action. In this drug discovery process, rhodesain and falcipain-2, of
Indexed as
Cysteine Proteinase InhibitorsNitrilesPlasmodium falciparumTrypanosoma brucei rhodesienseTrypanosomiasis, AfricanAntimalarialsCysteine EndopeptidasesHumansMalariaProtozoan ProteinsTrypanocidal AgentsAntimalarialsCysteine EndopeptidasesCysteine Proteinase InhibitorsNitrilesProtozoan ProteinsTrypanocidal Agentsneglected tropical diseasespoverty-related diseasesrhodesain and falcipain-2
Identifiers
PMID38673995
PMCPMC11050014
OpenAlexW4394891460
What OpenQuestion holds
Textmetadata
LicenceCC BY
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