Evidence map›Paper›PMID 38673910›Full record

ArticleInternational journal of molecular sciences2024

Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy.

Alex-Xianghua Zhou, Marie Jeansson, Liqun He, Leif Wigge, Pernilla Tonelius, Ramesh Tati, Linda Cederblad, Lars Muhl, Martin Uhrbom, Jianping Liu and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Alex-Xianghua ZhouResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.ORCID 0000-0002-3734-4638
Marie JeanssonDepartment of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0003-1075-8563
Liqun HeDepartment of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0003-2127-7597
Leif WiggeData Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.ORCID 0000-0003-4153-5354
Pernilla ToneliusResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.
Ramesh TatiResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.
Linda CederbladResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.
Lars MuhlDepartment of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.
Martin UhrbomResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.ORCID 0009-0006-5417-1210
Jianping LiuDepartment of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0002-7336-3895
Anna Björnson GranqvistResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-3271-3887
Christer BetsholtzDepartment of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.
Pernille B L HansenResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43162 Mölndal, Sweden.
AstraZeneca (Sweden) · SEKarolinska Institutet · SEUppsala University · SEMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial cell (EC) injury is a crucial contributor to the progression of diabetic kidney disease (DKD), but the specific EC populations and mechanisms involved remain elusive. Kidney ECs (

Indexed as

Alternative SplicingDiabetic NephropathiesEndothelial CellsSingle-Cell AnalysisTranscriptomeAnimalsGene Expression ProfilingGene Expression RegulationKidneyMaleMiceTranscription, Geneticdiabetic nephropathyendotheliumtranscriptomics

Identifiers

PMID38673910
PMCPMC11050020
OpenAlexW4394821639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.