Evidence map›Paper›PMID 38673903›Full record

ArticleInternational journal of molecular sciences2024

Evaluation of Ouabain's Tissue Distribution in C57/Black Mice Following Intraperitoneal Injection, Using Chromatography and Mass Spectrometry.

Denis A Abaimov, Rogneda B Kazanskaya, Ruslan A Ageldinov, Maxim S Nesterov, Yulia A Timoshina, Angelina I Platova, Irina J Aristova, Irina S Vinogradskaia, Tatiana N Fedorova, Anna B Volnova and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Steroid hormone ouabain cooperates with NaActa pharmaceutica Sinica. B · 2026
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Denis A AbaimovResearch Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia.ORCID 0000-0001-6888-3223
Rogneda B KazanskayaResearch Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia.
Ruslan A AgeldinovScientific Center for Biomedical Technologies of the Federal Biomedical Agency of Russia, 119435 Krasnogorsk, Russia.ORCID 0000-0003-0369-5170
Maxim S NesterovScientific Center for Biomedical Technologies of the Federal Biomedical Agency of Russia, 119435 Krasnogorsk, Russia.
Yulia A TimoshinaResearch Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia.
Angelina I PlatovaThe Mental Health Research Center, Kashirskoye Shosse 34, 115522 Moscow, Russia.
Irina J AristovaBiological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 St. Petersburg, Russia.
Irina S VinogradskaiaNon-State Private Educational Institution of Higher Professional Education, Moscow University for Industry and Finance "Synergy", Meshchanskaya Street, 9/14, Building 1, 129090 Moscow, Russia.ORCID 0009-0009-7633-182X
Tatiana N FedorovaResearch Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia.
Anna B VolnovaBiological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 St. Petersburg, Russia.ORCID 0000-0003-0724-887X
Raul R GainetdinovInstitute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 St. Petersburg, Russia.
Alexander V LopachevResearch Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia.
St Petersburg University · RUResearch Center of Neurology · RULomonosov Moscow State University · RUMental Health Research Center of Russian Academy of Medical Sciences · RUMoscow University «Synergy» · RU

Funding

Russian Science Foundation 22-75-10131Saint-Petersburg State University 95444211
6 · The paper itself

Abstract

Cardiotonic steroids (CTSs), such as digoxin, are used for heart failure treatment. However, digoxin permeates the brain-blood barrier (BBB), affecting central nervous system (CNS) functions. Finding a CTS that does not pass through the BBB would increase CTSs' applicability in the clinic and decrease the risk of side effects on the CNS. This study aimed to investigate the tissue distribution of the CTS ouabain following intraperitoneal injection and whether ouabain passes through the BBB. After intraperitoneal injection (1.25 mg/kg), ouabain concentrations were measured at 5 min, 15 min, 30 min, 1 h, 3 h, 6 h, and 24 h using HPLC-MS in brain, heart, liver, and kidney tissues and blood plasma in C57/black mice. Ouabain was undetectable in the brain tissue. Plasma: C

Indexed as

Mice, Inbred C57BLOuabainAnimalsBlood-Brain BarrierBrainCardiotonic AgentsChromatography, High Pressure LiquidInjections, IntraperitonealKidneyLiverMaleMass SpectrometryMiceMyocardiumTissue DistributionCardiotonic AgentsOuabainblood plasmabrainbrain–blood barriercardiac tissuecardiotonic steroidsdigoxinkidneyliverouabain

Identifiers

PMID38673903
PMCPMC11050293
OpenAlexW4394821638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.