Evidence map›Paper›PMID 38673860›Full record

ArticleInternational journal of molecular sciences2024

Synthesis of Estrone Heterodimers and Evaluation of Their In Vitro Antiproliferative Activity.

Noémi Bózsity, Viktória Nagy, Johanna Szabó, Balázs Pálházi, Zoltán Kele, Vivien Resch, Gábor Paragi, István Zupkó, Renáta Minorics, Erzsébet Mernyák

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noémi BózsityInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.ORCID 0000-0002-7907-7734
Viktória NagyInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Johanna SzabóDepartment of Analytical and Molecular Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
Balázs PálháziDepartment of Analytical and Molecular Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
Zoltán KeleDepartment of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
Vivien ReschDepartment of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
Gábor ParagiDepartment of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
István ZupkóInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.ORCID 0000-0003-3243-5300
Renáta MinoricsInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Erzsébet MernyákDepartment of Analytical and Molecular Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.

Funding

Ministry of Innovation and Technology of Hungary TKP2021-EGA-17National Research, Development and Innovation Office K 143690National Research, Development and Innovation Office SNN 139323
6 · The paper itself

Abstract

Directed structural modifications of natural products offer excellent opportunities to develop selectively acting drug candidates. Natural product hybrids represent a particular compound group. The components of hybrids constructed from different molecular entities may result in synergic action with diminished side effects. Steroidal homo- or heterodimers deserve special attention owing to their potentially high anticancer effect. Inspired by our recently described antiproliferative core-modified estrone derivatives, here, we combined them into heterodimers via Cu(I)-catalyzed azide-alkyne cycloaddition reactions. The two

Indexed as

Antineoplastic AgentsCell ProliferationEstroneApoptosisCell Line, TumorDimerizationDrug Screening Assays, AntitumorFemaleHeLa CellsHumansMCF-7 CellsMolecular Docking SimulationTubulinAntineoplastic AgentsEstroneTubulin13α-estroneantiproliferative effectD-secoestroneheterodimertaxoid binding site of tubulintubulin polymerization

Identifiers

PMID38673860
PMCPMC11050183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.