Evidence map›Paper›PMID 38673852›Full record

ArticleInternational journal of molecular sciences2024

Link Protein 1 Is Involved in the Activity-Dependent Modulation of Perineuronal Nets in the Spinal Cord.

Judith Sánchez-Ventura, Natalia Lago, Clara Penas, Xavier Navarro, Esther Udina

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Special Issue "Plasticity of the Nervous System After Injury: 2nd Edition".International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Judith Sánchez-VenturaDepartment Cell Biology, Physiology and Immunology, Institute of Neuroscience, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0001-6143-0440
Natalia LagoDepartment Cell Biology, Physiology and Immunology, Institute of Neuroscience, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-5631-8558
Clara PenasDepartment Cell Biology, Physiology and Immunology, Institute of Neuroscience, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Xavier NavarroDepartment Cell Biology, Physiology and Immunology, Institute of Neuroscience, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0001-9849-902X
Esther UdinaDepartment Cell Biology, Physiology and Immunology, Institute of Neuroscience, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0003-1954-8562
Universitat Autònoma de Barcelona · ES

Funding

Fundació la Marató de TV3 TV3-201736-30-31
6 · The paper itself

Abstract

One of the challenges of the mature nervous system is to maintain the stability of neural networks while providing a degree of plasticity to generate experience-dependent modifications. This plasticity-stability dynamism is regulated by perineuronal nets (PNNs) and is crucial for the proper functioning of the system. Previously, we found a relation between spinal PNNs reduction and maladaptive plasticity after spinal cord injury (SCI), which was attenuated by maintaining PNNs with activity-dependent therapies. Moreover, transgenic mice lacking the cartilage link protein 1 (

Indexed as

Extracellular Matrix ProteinsMice, KnockoutSpinal CordSpinal Cord InjuriesAnimalsMaleMiceMice, Inbred C57BLMotor NeuronsNerve NetNeuronal PlasticityProteoglycan Link ProteinProteoglycansExtracellular Matrix ProteinsProteoglycan Link ProteinProteoglycansactivity-dependent therapylink protein 1maladaptive plasticityperineuronal netsspinal cord injury

Identifiers

PMID38673852
PMCPMC11050079
OpenAlexW4394755326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.