Evidence map›Paper›PMID 38673823›Full record

ArticleInternational journal of molecular sciences2024

Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents.

Elena P Khashchenko, Mikhail Yu Vysokikh, Maria V Marey, Ksenia O Sidorova, Ludmila A Manukhova, Natalya N Shkavro, Elena V Uvarova, Vladimir D Chuprynin, Timur Kh Fatkhudinov, Leila V Adamyan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Glucose metabolism in osteoporosis: A potential therapeutic target (Review).International journal of molecular medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Elena P KhashchenkoFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.ORCID 0000-0002-3195-307X
Mikhail Yu VysokikhFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.ORCID 0000-0002-4047-6201
Maria V MareyFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.
Ksenia O SidorovaFaculty of Medicine and Biology, Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., 117997 Moscow, Russia.
Ludmila A ManukhovaFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.ORCID 0009-0002-1670-1728
Natalya N ShkavroFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.
Elena V UvarovaFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.
Vladimir D ChupryninFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.
Timur Kh FatkhudinovFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.ORCID 0000-0002-6498-5764
Leila V AdamyanFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.
Gennady T SukhikhFSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov", Ministry of Healthcare of the Russian Federation, 4, Oparina Str., 117997 Moscow, Russia.
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation · RUSechenov University · RULomonosov Moscow State University · RUPeoples' Friendship University of Russia · RUPirogov Russian National Research Medical University · RU

Funding

The work was carried out with the financial support of the state assignment of Ministry of Health "The role of energy metabolism and immune defense disorders in the development of various forms of endometriosis, the development of personalized therapy and 18-A21
6 · The paper itself

Abstract

Energy metabolism plays a pivotal role in the pathogenesis of endometriosis. For the initial stages of the disease in adolescents, this aspect remains unexplored. The objective of this paper was to analyze the association of cellular and endosomal profiles of markers of glycolysis, mitochondrial biogenesis, apoptosis, autophagy and estrogen signaling in peritoneal endometriosis (PE) in adolescents. We included 60 girls aged 13-17 years in a case-control study: 45 with laparoscopically confirmed PE (main group) and 15 with paramesonephric cysts (comparison group). Samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (Erα/β), hexokinase (Hex2), pyruvate dehydrogenase kinase (PDK1), glucose transporter (Glut1), monocarboxylate transporters (MCT1 and MCT2), optic atrophy 1 (OPA1, mitochondrial fusion protein), dynamin-related protein 1 (DRP1, mitochondrial fission protein), Bax, Bcl2, Beclin1, Bnip3, P38 mitogen-activated protein kinase (MAPK), hypoxia-inducible factor 1 (Hif-1α), mitochondrial voltage-dependent anion channel (VDAC) and transforming growth factor (TGFβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (Western-Blot and PCR). The analysis identified higher levels of molecules associated with proliferation (ERβ), glycolysis (MCT2, PDK1, Glut1, Hex2, TGFβ and Hif-1α), mitochondrial biogenesis (OPA1, DRP1) and autophagy (P38, Beclin1 and Bnip3) and decreased levels of apoptosis markers (

Indexed as

ApoptosisAutophagyEndometriosisGlycolysisAdolescentBiomarkersCase-Control StudiesEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansOrganelle BiogenesisSignal TransductionBiomarkersEstrogen Receptor alphaEstrogen Receptor betaadolescentsapoptosisautophagyBcl-2estrogen receptor βexosomesglycolysisHif-1αmitochondrial biogenesisperitoneal endometriosisproliferationTGFβ

Identifiers

PMID38673823
PMCPMC11050237
OpenAlexW4394726364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.