Evidence map›Paper›PMID 38673796›Full record

ArticleInternational journal of molecular sciences2024

A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation-A Microstructural Volumetric Analysis in a Rodent Model.

Marius Heitzer, Philipp Winnand, Mark Ooms, Zuzanna Magnuska, Fabian Kiessling, Eva Miriam Buhl, Frank Hölzle, Ali Modabber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marius HeitzerDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074 Aachen, Germany.ORCID 0000-0002-9205-6065
Philipp WinnandDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074 Aachen, Germany.ORCID 0000-0001-8315-7684
Mark OomsDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074 Aachen, Germany.ORCID 0000-0002-9785-9502
Zuzanna MagnuskaInstitute for Experimental Molecular Imaging, RWTH Aachen University, Forckenbeckstraße 55, 52074 Aachen, Germany.
Fabian KiesslingInstitute for Experimental Molecular Imaging, RWTH Aachen University, Forckenbeckstraße 55, 52074 Aachen, Germany.ORCID 0000-0002-7341-0399
Eva Miriam BuhlInstitute for Pathology, Electron Microscopy Facility, University Hospital RWTH Aachen, Pauwelstraße 30, 52074 Aachen, Germany.
Frank HölzleDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074 Aachen, Germany.
Ali ModabberDepartment of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelstraße 30, 52074 Aachen, Germany.ORCID 0000-0003-2160-4527
RWTH Aachen University · DE

Funding

START-Program of the Faculty of Medicine of the Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University 115/20
6 · The paper itself

Abstract

In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential of VIVO in terms of bone regeneration has not yet been explored. The present rodent study compared the post-extraction bone healing of a collagen sponge (COSP) and VIVO in the context of ongoing anticoagulation therapy. According to a split-mouth design, a total of 178 extraction sockets were generated under rivaroxaban treatment, of which 89 extraction sockets were treated with VIVO and 89 with COSP. Post-extraction bone analysis was conducted via in vivo micro-computed tomography (µCT), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) after 5, 10, and 90 days. During the observation time of 90 days, µCT analysis revealed that VIVO and COSP led to significant increases in both bone volume and bone density (

Indexed as

AnticoagulantsBone RegenerationTooth ExtractionX-Ray MicrotomographyAlveolar Bone LossAnimalsCollagenMaleRatsTissue AdhesivesAnticoagulantsCollagenTissue Adhesivesbiodegradable adhesivebone regenerationsocket preservationtissue adhesivestooth extraction

Identifiers

PMID38673796
PMCPMC11049800
OpenAlexW4394721090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.