Evidence map›Paper›PMID 38673753›Full record

ArticleInternational journal of molecular sciences2024

Chromosomal Damage, Chromosome Instability, and Polymorphisms in

Fernando Aldana-Salazar, Nelson Rangel, María José Rodríguez, César Baracaldo, María Martínez-Agüero, Milena Rondón-Lagos

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Fernando Aldana-SalazarSchool of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia.ORCID 0000-0003-2252-7965
Nelson RangelDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.ORCID 0000-0002-9709-2196
María José RodríguezSchool of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia.
César BaracaldoDoctoral Program in Biological and Environmental Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia.
María Martínez-AgüeroCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá 110231, Colombia.ORCID 0000-0001-6450-0184
Milena Rondón-LagosSchool of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia.ORCID 0000-0002-3160-9316
Pedagogical and Technological University of Colombia · COPontificia Universidad Javeriana · COUniversidad del Rosario · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the department of Boyacá, Colombia, agriculture stands as one of the primary economic activities. However, the escalating utilization of pesticides within this sector has sparked concern regarding its potential correlation with elevated risks of genotoxicity, chromosomal alterations, and carcinogenesis. Furthermore, pesticides have been associated with a broad spectrum of genetic polymorphisms that impact pivotal genes involved in pesticide metabolism and DNA repair, among other processes. Nonetheless, our understanding of the genotoxic effects of pesticides on the chromosomes (as biomarkers of effect) in exposed farmers and the impact of genetic polymorphisms (as susceptibility biomarkers) on the increased risk of chromosomal damage is still limited. The aim of our study was to evaluate chromosomal alterations, chromosomal instability, and clonal heterogeneity, as well as the presence of polymorphic variants in the

Indexed as

Chromosomal InstabilityFarmersGlutathione S-Transferase piOccupational ExposurePesticidesX-ray Repair Cross Complementing Protein 1AdultBiomarkersChromosome AberrationsColombiaFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideBiomarkersGlutathione S-Transferase piGSTP1 protein, humanPesticidesX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanchromosomal instabilityclonal heterogeneityFISHpesticidespolymorphismrestriction enzymes

Identifiers

PMID38673753
PMCPMC11050655
OpenAlexW4394685726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.