Evidence map›Paper›PMID 38673466›Full record

ReviewJournal of clinical medicine2024

Safe and Informed Use of Gadolinium-Based Contrast Agent in Body Magnetic Resonance Imaging: Where We Were and Where We Are.

Francesca Iacobellis, Marco Di Serafino, Camilla Russo, Roberto Ronza, Martina Caruso, Giuseppina Dell'Aversano Orabona, Costanza Camillo, Vittorio Sabatino, Dario Grimaldi, Chiara Rinaldo and 6 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesca IacobellisDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.ORCID 0000-0003-4604-7384
Marco Di SerafinoDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.ORCID 0000-0001-6972-1859
Camilla RussoNeuroradiology Unit, Department of Neuroscience Santobono-Pausilipon Children's Hospital, 80122 Naples, Italy.ORCID 0000-0002-2256-7281
Roberto RonzaDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Martina CarusoDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Giuseppina Dell'Aversano OrabonaDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Costanza CamilloDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Vittorio SabatinoDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Dario GrimaldiDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Chiara RinaldoDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Luigi BarbutoDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Francesco VerdeDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Giuliana GiacobbeDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
Maria Laura SchilliròDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.ORCID 0000-0003-1002-2388
Enrico ScaranoDepartment of Radiology, "San Carlo" Hospital, 85100 Potenza, Italy.
Luigia RomanoDepartment of General and Emergency Radiology, "A. Cardarelli" Hospital, 80131 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gadolinium-based contrast agents (GBCAs) have helped to improve the role of magnetic resonance imaging (MRI) for the diagnosis and treatment of diseases. There are currently nine different commercially available gadolinium-based contrast agents (GBCAs) that can be used for body MRI cases, and which are classifiable according to their structures (cyclic or linear) or biodistribution (extracellular-space agents, target/specific-agents, and blood-pool agents). The aim of this review is to illustrate the commercially available MRI contrast agents, their effect on imaging, and adverse reaction on the body, with the goal to lead to their proper selection in different clinical contexts. When we have to choose between the different GBCAs, we have to consider several factors: (1) safety and clinical impact; (2) biodistribution and diagnostic application; (3) higher relaxivity and better lesion detection; (4) higher stability and lower tissue deposit; (5) gadolinium dose/concentration and lower volume injection; (6) pulse sequences and protocol optimization; (7) higher contrast-to-noise ratio at 3.0 T than at 1.5 T. Knowing the patient's clinical information, the relevant GBCAs properties and their effect on body MRI sequences are the key features to perform efficient and high-quality MRI examination.

Indexed as

adverse effectcontrast mediacontrast mediumgadoliniumgadolinium-based contrast agents (GBCAs)hepatobiliary contrast agentshepatobiliary imagingimaging sequencesmagnetic resonance imagingMR cholangiography

Identifiers

PMID38673466
PMCPMC11051151

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.