ReviewJournal of clinical medicine2024
Isthmocele and Infertility.
Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Investigating the clinical manifestations associated with isthmocele: a meta-analysis study.Archives of gynecology and obstetrics · 2025Pooled it
- Comparative analysis of extraperitoneal versus transabdominal cesarean sections: a meta-analysis of randomized controlled trials and systematic review.BMC surgery · 2025Pooled it
- High live birth rates after laparoscopic isthmocele repair in infertility: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Reproductive and clinical outcomes after minimally invasive isthmocele repair: a comparison of robotic-assisted and laparoscopic approaches.Archives of gynecology and obstetrics · 2026Article
- Determinants of First-Trimester Residual Myometrial Thickness After Previous Cesarean Delivery: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Comparison of four imaging modalities for cesarean scar defect: a retrospective study.BMC women's health · 2026Article
- Isthmocele: from Detection to Treatment: A Narrative Review.Advances in therapy · 2026Review
- Isthmocele: from Detection to Treatment: A Narrative Review.Advances in therapy · 2026Review
- Impact of obstetric and surgical factors on isthmocele development: insights from a prospective cohort study.Archives of gynecology and obstetrics · 2026Article
- Reproductive outcomes following assisted reproductive technology after previous caesarean section: data from the Swiss National Registry.Frontiers in endocrinology · 2026Article
- The Rising Global Cesarean Section Rates and Their Impact on Maternal and Child Health: A Scoping Review.Journal of clinical medicine · 2025Review
- Indocyanine green (ICG) imaging: case report of innovative isthmocele diagnosis and repair in a post-ablation patient and literature review.Archives of gynecology and obstetrics · 2025Review
- A comparison between laparoscopy and hysteroscopy approaches in the treatment of symptomatic isthmocele: A systematic review and meta-analysis.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Hysteroscopic niche resection can effectively reduce the niche volume, increase residual myometrial thickness, and improve postmenstrual spotting symptoms.Archives of gynecology and obstetrics · 2025Observational
- Article
- High Risk of Chronic Endometritis in Isthmocele-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Caesarean Scar Endometrial Defects Contribute to Post-Caesarean Abnormal Uterine Bleeding and Chronic Endometritis: A Retrospective Case-Control Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Reproductive outcomes in women with prior cesarean scar pregnancies over six years.Scientific reports · 2025Article
- Improving Precision and Safety in Uterine Isthmocele Repair by Utilizing the KOH Cup and Firefly Guidance.Cureus · 2025Article
- Analysis of outcomes of laparotomic, laparoscopic, and hysteroscopic symptomatic ısthmocele (niche) repair in Turkish women.Revista da Associacao Medica Brasileira (1992) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman's quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT >2.5-3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.