Evidence map›Paper›PMID 38673053›Full record

ArticleJournal of personalized medicine2024

Gene Variants of the OAS/RNase L Pathway and Their Association with Severity of Symptoms and Outcome of SARS-CoV-2 Infection.

Aurelio Perez-Favila, Sonia Sanchez-Macias, Sergio A Oropeza De Lara, Idalia Garza-Veloz, Roxana Araujo-Espino, Maria E Castañeda-Lopez, Alejandro Mauricio-Gonzalez, Sodel Vazquez-Reyes, Perla Velasco-Elizondo, Perla M Trejo-Ortiz and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. The FunctionalInternational journal of molecular sciences · 2026
    Article
  4. Overexpression ofJournal of clinical medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Aurelio Perez-FavilaLaboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Sonia Sanchez-MaciasLaboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Sergio A Oropeza De LaraLaboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Idalia Garza-VelozLaboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.ORCID 0000-0002-6307-1696
Roxana Araujo-EspinoDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Maria E Castañeda-LopezDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Alejandro Mauricio-GonzalezDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Sodel Vazquez-ReyesDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.ORCID 0000-0002-9435-5499
Perla Velasco-ElizondoDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Perla M Trejo-OrtizDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Fabiana E Mollinedo MontañoDoctorado en Ciencias con Orientación en Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Claudia Castruita-De la RosaLaboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.
Margarita L Martinez-FierroLaboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.ORCID 0000-0003-1478-9068
Universidad Autónoma de Zacatecas "Francisco García Salinas" · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe interferon pathway plays a critical role in triggering the immune response to SARS-CoV-2, and these gene variants may be involved in the severity of COVID-19. This study aimed to analyze the frequency of three gene variants of

methodsThis cross-sectional study included 104 patients with SARS-CoV-2 infection, of which 34 were asymptomatic COVID-19, and 70 were symptomatic cases. The variants rs486907 (

resultsPatients with the allele C of the

conclusionsOur data indicate that individuals carrying the C allele of the

Indexed as

coronavirusCOVID-19gene variantOASpolymorphismRNASELSARS-CoV-2

Identifiers

PMID38673053
PMCPMC11051515
OpenAlexW4394892083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.