Evidence map›Paper›PMID 38672904›Full record

ReviewFoods (Basel, Switzerland)2024

Comprehensive Review of EGCG Modification: Esterification Methods and Their Impacts on Biological Activities.

Yingjun Zhuang, Wei Quan, Xufeng Wang, Yunhui Cheng, Ye Jiao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yingjun ZhuangSchool of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha 410114, China.
Wei QuanCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0001-8305-2778
Xufeng WangSchool of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha 410114, China.
Yunhui ChengSchool of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha 410114, China.
Ye JiaoSchool of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha 410114, China.
Changsha University of Science and Technology · CNHunan Agricultural University · CN

Funding

the National Natural Science Foundation of China No.32102114the National Natural Science Foundation of China No.32302258the Natural Science Foundation of Hunan Province No. 2021JJ40566
6 · The paper itself

Abstract

Epigallocatechin gallate (EGCG), the key constituent of tea polyphenols, presents challenges in terms of its lipid solubility, stability, and bioavailability because of its polyhydroxy structure. Consequently, structural modifications are imperative to enhance its efficacy. This paper comprehensively reviews the esterification techniques applied to EGCG over the past two decades and their impacts on bioactivities. Both chemical and enzymatic esterification methods involve catalysts, solvents, and hydrophobic groups as critical factors. Although the chemical method is cost-efficient, it poses challenges in purification; on the other hand, the enzymatic approach offers improved selectivity and simplified purification processes. The biological functions of EGCG are inevitably influenced by the structural changes incurred through esterification. The antioxidant capacity of EGCG derivatives can be compromised under certain conditions by reducing hydroxyl groups, while enhancing lipid solubility and stability can strengthen their antiviral, antibacterial, and anticancer properties. Additionally, esterification broadens the utility of EGCG in food applications. This review provides critical insights into developing cost-effective and environmentally sustainable selective esterification methods, as well as emphasizes the elucidation of the bioactive mechanisms of EGCG derivatives to facilitate their widespread adoption in food processing, healthcare products, and pharmaceuticals.

Indexed as

biological activitiesepigallocatechin gallate (EGCG)esterification

Identifiers

PMID38672904
PMCPMC11048832
OpenAlexW4394876507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.