Evidence map›Paper›PMID 38672565›Full record

ArticleCancers2024

Plasma IL-1 and IL-6 Family Cytokines with Soluble Receptor Levels at Diagnosis in Head and Neck Squamous Cell Carcinoma: High Levels Predict Decreased Five-Year Disease-Specific and Overall Survival.

Helene Hersvik Aarstad, Svein Erik Emblem Moe, Stein Lybak, Øystein Bruserud, Tor Henrik Anderson Tvedt, Hans Jørgen Aarstad

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Impact ofOncology research · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Helene Hersvik AarstadDepartment of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, 5009 Bergen, Norway.
Svein Erik Emblem MoeDepartment of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, 5009 Bergen, Norway.ORCID 0009-0003-1981-3968
Stein LybakDepartment of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, 5009 Bergen, Norway.
Øystein BruserudSection for Haematology, Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway.
Tor Henrik Anderson TvedtDepartment of Haematology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
Hans Jørgen AarstadDepartment of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, 5009 Bergen, Norway.
Haukeland University Hospital · NOOslo University Hospital · NO

Funding

Norwegian Cancer Society 182609Norwegian Central Health West authorities F-12125
6 · The paper itself

Abstract

Activation of the acute-phase cascade (APC) has been correlated with outcomes in various cancers, including head and neck squamous cell carcinoma (HNSCC). Primary drivers of the APC are the cytokines within the interleukin-6 (IL-6) and IL-1 families. Plasma levels of IL-6 family cytokines/soluble receptors (IL-6, IL-27, IL-31, OSM, CNTF, soluble (s-)gp130, s-IL-6Rα) and IL-1 family members (IL-1RA, s-IL-33Rα) were determined at diagnosis for 87 human papillomavirus (HPV)-negative (-) HNSCC patients. We then studied the 5-year Disease-Specific Survival (DSS) and Overall Survival (OS). Increased plasma levels of IL-6 (

Indexed as

gp130head and neck squamous cell carcinomaHPVIL-31IL-6TNM stage

Identifiers

PMID38672565
PMCPMC11048558
OpenAlexW4394768793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.