Evidence map›Paper›PMID 38672482›Full record

ArticleBiomolecules2024

Hyaluronic Acid Prevents Fusion of Brain Tumor-Derived Spheroids and Selectively Alters Their Gene Expression Profile.

Irina Arutyunyan, Anna Soboleva, Dorzhu Balchir, Enar Jumaniyazova, Vera Kudelkina, Andrey Elchaninov, Timur Fatkhudinov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Irina ArutyunyanNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov Ministry of Healthcare of the Russian Federation, 4 Oparina Street, 117997 Moscow, Russia.ORCID 0000-0002-4344-8943
Anna SobolevaResearch Institute of Molecular and Cellular Medicine, RUDN University, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-9158-1933
Dorzhu BalchirResearch Institute of Molecular and Cellular Medicine, RUDN University, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Enar JumaniyazovaResearch Institute of Molecular and Cellular Medicine, RUDN University, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0002-8226-0433
Vera KudelkinaAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution Petrovsky National Research Centre of Surgery, 3 Tsyurupy Street, 117418 Moscow, Russia.ORCID 0000-0002-2620-7427
Andrey ElchaninovNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov Ministry of Healthcare of the Russian Federation, 4 Oparina Street, 117997 Moscow, Russia.ORCID 0000-0002-2392-4439
Timur FatkhudinovNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov Ministry of Healthcare of the Russian Federation, 4 Oparina Street, 117997 Moscow, Russia.ORCID 0000-0002-6498-5764
Peoples' Friendship University of Russia · RUResearch Institute of Human Morphology · RU

Funding

Ministry of Science and Higher Education No. 075-15-2021-1060Russian Science Foundation 22-15-00241This study was supported by the Ministry of Science and Higher Education of the Russian Fed-eration 075-15-2021-1060
6 · The paper itself

Abstract

Hyaluronic acid (HA), a major glycosaminoglycan of the brain extracellular matrix, modulates cell behaviors through binding its receptor, Cd44. In this study, we assessed the influence of HA on high-grade brain tumors in vitro. The model comprised cell cultures derived from six rodent carcinogen-induced brain tumors, forming 3D spheroids prone to spontaneous fusion. Supplementation of the standard culture medium with 0.25% HA significantly inhibited the fusion rates, preserving the shape and size uniformity of spheroids. The 3D cultures were assigned to two groups; a

Indexed as

Brain NeoplasmsHyaluronan ReceptorsHyaluronic AcidSOXB1 Transcription FactorsSpheroids, CellularAnimalsCell FusionGene Expression Regulation, NeoplasticRatsTranscriptomeTumor Cells, CulturedHyaluronan ReceptorsHyaluronic AcidSox2 protein, ratSOXB1 Transcription Factors3D culturehigh-grade brain tumorshyaluronic acidspheroid fusionspheroidstissue strains

Identifiers

PMID38672482
PMCPMC11048098
OpenAlexW4394681322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.