Evidence map›Paper›PMID 38672476›Full record

ArticleBiomolecules2024

Neurosteroid Modulation of Synaptic and Extrasynaptic GABA

Scott J Mitchell, Grant D Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J Martin, Jerome D Swinny, Louise Kelly, John R Atack, Michael Paradowski and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Scott J MitchellDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.ORCID 0000-0002-1232-2897
Grant D PhillipsDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
Becks TenchDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.ORCID 0000-0003-3032-7306
Yunkai LiDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
Delia BelelliDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.
Stephen J MartinDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.ORCID 0000-0003-0805-8541
Jerome D SwinnySchool of Pharmacy & Biomedical Sciences, St. Michael's Building, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.
Louise KellySchool of Pharmacy & Biomedical Sciences, St. Michael's Building, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.ORCID 0000-0002-5119-519X
John R AtackMain Building, Medicines Discovery Institute, Park Place, Cardiff University, Cardiff, CF10 3AT, UK.
Michael ParadowskiMain Building, Medicines Discovery Institute, Park Place, Cardiff University, Cardiff, CF10 3AT, UK.ORCID 0000-0003-3857-0116
Jeremy J LambertDivision of Cellular & Systems Medicine, School of Medicine, Medical Sciences Institute, Dundee University, Dow Street, Dundee DD1 5HL, UK.ORCID 0000-0002-4204-3602
University of Dundee · GBCardiff University · GBUniversity of Portsmouth · GB

Funding

Medical Research Council Studentship 1313951Wellcome TrustWellcome Trust 221617/Z/20/Z
6 · The paper itself

Abstract

The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these potent enhancers of GABA

Indexed as

NeurosteroidsNucleus AccumbensPregnanoloneReceptors, GABA-AAnimalsFemaleMaleMiceMice, Inbred C57BLNeuronsSynapsesSynaptic TransmissionNeurosteroidsPregnanoloneReceptors, GABA-Aallopregnanolonebrexanolonenucleus accumbensphasic inhibitiontonic inhibitionzuranolone GABAA receptor

Identifiers

PMID38672476
PMCPMC11048561
OpenAlexW4394686041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.