Evidence map›Paper›PMID 38672452›Full record

ArticleBiomolecules2024

COVID-Vaccines in Pregnancy: Maternal and Neonatal Response over the First 9 Months after Delivery.

Alice Proto, Stefano Agliardi, Arianna Pani, Silvia Renica, Gianluca Gazzaniga, Riccardo Giossi, Michele Senatore, Federica Di Ruscio, Daniela Campisi, Chiara Vismara and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
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  4. Observational
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  6. BronchStop Study Protocol, Season 2.NIHR open research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alice ProtoNeonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.ORCID 0000-0003-0829-7796
Stefano AgliardiDepartment of Medical Biotechnology and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-9765-5529
Arianna PaniDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-6464-2596
Silvia RenicaDepartment of Biomedical, Surgical and Dental Sciences, Postgraduate School of Microbiology and Virology, University of Milan, 20122 Milan, Italy.
Gianluca GazzanigaDepartment of Medical Biotechnology and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-0648-3309
Riccardo GiossiChemical-Clinical and Microbiological Analyses Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.ORCID 0000-0002-7352-9445
Michele SenatoreChemical-Clinical and Microbiological Analyses Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.ORCID 0000-0003-3303-3186
Federica Di RuscioDepartment of Biomedical, Surgical and Dental Sciences, Postgraduate School of Microbiology and Virology, University of Milan, 20122 Milan, Italy.
Daniela CampisiChemical-Clinical and Microbiological Analyses Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.
Chiara VismaraChemical-Clinical and Microbiological Analyses Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.
Valentina PanettaL'altrastatisticasrl, Consultancy & Training, Biostatistics Office, 00174 Rome, Italy.ORCID 0000-0001-6058-5045
Francesco ScaglioneDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-8554-2401
Stefano MartinelliNeonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.ORCID 0000-0002-2155-8535
University of Milan · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITData Management (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination against SARS-CoV-2 has been demonstrated to be safe during gestation. Nevertheless, there are no robust data investigating the entity of maternal antibodies' transmission through the placenta to the newborn and the persistence of the antibodies in babies' serum. The objective of this study is to assess the maternal antibody transmission and kinetics among newborns in the first months of life. Women having received one or two doses of anti-SARS-CoV-2 mRNA-vaccines during pregnancy at any gestational age, and their newborns, were recruited and followed-up over 9 months. Ninety-eight women and 103 babies were included. At birth, we observed a significant positive correlation between maternal and neonatal serum anti-SARS-CoV-2 antibody levels and a significant negative correlation between the time since last dose and antibody levels in mothers with two doses. Over the follow-up, the birth antibody level significantly decreased in time according to the received doses number at 3, 6, and 9 months. During the follow-up, we registered 34 dyad SARS-CoV-2 infection cases. The decreasing trend was slower in the SARS-CoV-2 infection group and among breastfed non-infected babies. Antibodies from maternal anti-SARS-CoV-2 vaccination are efficiently transferred via the placenta and potentially even through breast milk. Among newborns, antibodies show relevant durability in the first months of life.

Indexed as

Antibodies, ViralCOVID-19COVID-19 VaccinesSARS-CoV-2AdultFemaleHumansInfantInfant, NewbornPregnancyPregnancy Complications, InfectiousVaccinationAntibodies, ViralCOVID-19 VaccinesbreastfeedingCOVID-vaccinesneonatologypharmacologypregnancySARS-CoV-2

Identifiers

PMID38672452
PMCPMC11048428
OpenAlexW4393899258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.