Evidence map›Paper›PMID 38672451›Full record

ArticleBiomolecules2024

Serum Neuron-Specific Enolase as a Biomarker of Neonatal Brain Injury-New Perspectives for the Identification of Preterm Neonates at High Risk for Severe Intraventricular Hemorrhage.

Dimitra Metallinou, Grigorios Karampas, Maria-Loukia Pavlou, Maria-Ioanna Louma, Aimilia Mantzou, Antigoni Sarantaki, Christina Nanou, Kleanthi Gourounti, Maria Tzeli, Nikoletta Pantelaki and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Dimitra MetallinouDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.ORCID 0000-0003-1788-3818
Grigorios KarampasSecond Department of Obstetrics and Gynaecology, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Maria-Loukia PavlouDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.ORCID 0009-0004-7011-7324
Maria-Ioanna LoumaDepartment of Biochemistry & Biotechnology, University of Thessaly, 41500 Larissa, Greece.
Aimilia MantzouDivision of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, Medical School, Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-6606-8647
Antigoni SarantakiDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.ORCID 0000-0003-3316-8566
Christina NanouDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.
Kleanthi GourountiDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.
Maria TzeliDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.
Nikoletta PantelakiDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.
Evangelos TzamakosDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.
Theodora BoutsikouDepartment of Neonatology, School of Medicine, Aretaieio Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Aikaterini LykeridouDepartment of Midwifery, University of West Attica, 12243 Athens, Greece.
Nicoletta IacovidouDepartment of Neonatology, School of Medicine, Aretaieio Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece.
University of West Attica · GRNational and Kapodistrian University of Athens · GRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 days of life in preterm neonates (<34 weeks) that later developed brain injury in the form of either periventricular leukomalacia (PVL) or intraventricular hemorrhage (IVH) during their hospitalization. Participants were recruited from one neonatal intensive care unit, and on the basis of birth weight and gestational age, we matched each case (

Indexed as

BiomarkersInfant, PrematurePhosphopyruvate HydrataseBrain InjuriesCase-Control StudiesCerebral HemorrhageCerebral Intraventricular HemorrhageFemaleGestational AgeHumansInfant, NewbornLeukomalacia, PeriventricularMalePrognosisProspective StudiesBiomarkersENO2 protein, humanPhosphopyruvate Hydratasebiomarkersbrain injuryintraventricular hemorrhageneonatal intensive care unitneuron-specific enolaseperiventricular leukomalaciapreterm neonateserum

Identifiers

PMID38672451
PMCPMC11048112
OpenAlexW4393910801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.