Evidence map›Paper›PMID 38672422›Full record

ReviewBiomolecules2024

Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression.

Natalia A Osna, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, Sadatsugu Sakane, Raquel Carvalho Gontijo Weber, Hyun Young Kim and 15 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. [Liver organoid technology and its related progress in liver disease research].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  9. Article
  10. Canadian journal of gastroenterology & hepatology · 2025
    Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 3 countries.

Natalia A OsnaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68106, USA.ORCID 0000-0001-7498-0556
Irina TikhanovichDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Martí Ortega-RiberaDepartment of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8647-7069
Sebastian MuellerCenter for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0001-5655-6778
Chaowen ZhengCenter for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.
Johannes MuellerCenter for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.
Siyuan LiCenter for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.
Sadatsugu SakaneDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6306-4621
Raquel Carvalho Gontijo WeberDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Hyun Young KimDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Wonseok LeeDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Souradipta GangulyDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Yusuke KimuraDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Xiao LiuDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Debanjan DharDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8739-3684
Karin DiggleDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
David A BrennerDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Tatiana KisselevaDepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Neha AttalDepartment of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Iain H McKillopDepartment of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0003-2666-6727
Shilpa ChokshiThe Roger Williams Institute of Hepatology, Foundation for Liver Research, London SE59NT, UK.
Ram MahatoDepartment of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68106, USA.ORCID 0000-0003-3588-0434
Karuna RasineniDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68106, USA.ORCID 0000-0002-9581-3957
Gyongyi SzaboDepartment of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Kusum K KharbandaDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68106, USA.ORCID 0000-0001-7759-8889
University of California San Diego · USHeidelberg University · DEBeth Israel Deaconess Medical Center · USCarolinas Medical Center · USUniversity of Nebraska Medical Center · USKing's College London · GBNebraska Medical Center · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of Kansas Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIDEKAZU TSUKAMOTO · 1999 to 2026
$45.8M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
Transcriptional co-regulators and macrophage gene expressionR01DK091183 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2011 to 2025
$9.9M
Alcohol and Monocyte Signaling Administrative SupplementR01AA011576 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gyongyi Szabo · 1998 to 2026
$9.3M
The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and HeartP50AA030407 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Carol A. Casey · 2023 to 2026
$7.9M
MicroRNAs in Alcoholic Liver Disease Administrative SupplementR01AA020744 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2011 to 2023
$5.3M
Inactivation of Hepatic Stellate Cells During Reversal of Liver FibrosisR01DK099205 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2014 to 2025
$4.8M
TLR4 Signaling in alcoholic liver diseaseR01AA017729 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2009 to 2021
$4.3M
The Role of Portal Fibroblasts in Cholestatic Liver FibrosisR01DK101737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2014 to 2025
$3.8M
Novel IL-23 inhibitor for the treatment of alcohol associated liver diseaseU01AA029019 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA, LOOMBA, ROHIT · 2020 to 2024
$3.7M
Extracellular vesicles as the vehicles for promoting liver injury induced by HIV and alcoholR01AA027189 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OSNA, NATALIA ALEKSANDR, POLUEKTOVA, LARISA Y · 2019 to 2023
$2.6M
BLRD VA I01 BX004053BLRD VA I01 BX006064NIAAA NIH HHS P50 AA011999NIAAA NIH HHS P50 AA030407NIAAA NIH HHS R01 AA011576NIAAA NIH HHS R01 AA017729NIAAA NIH HHS R01 AA020744NIAAA NIH HHS R01 AA026723NIAAA NIH HHS R01 AA027189NIAAA NIH HHS R01 AA027586NIAAA NIH HHS R01 AA028550NIAAA NIH HHS R21 AA029241NIAAA NIH HHS U01 AA029019NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK091183NIDDK NIH HHS R01 DK099205NIDDK NIH HHS R01 DK101737NIDDK NIH HHS R01 DK111866NIDDK NIH HHS R01 DK133930NIDDK NIH HHS R01 DK135817NIDDK NIH HHS R01 DK137061NIDDK NIH HHS R44 DK115242NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.

Indexed as

Disease ProgressionLiver Diseases, AlcoholicAnimalsEpigenesis, GeneticHepatic Stellate CellsHumansLiveralcohol-associated liver diseasecell deathepigeneticsfatty acid binding protein 4fibrosishemolysishepatic stellate cellshepatocellular carcinomaMetAldmodels

Identifiers

PMID38672422
PMCPMC11048648
OpenAlexW4393235767

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.