Evidence map›Paper›PMID 38672402›Full record

ReviewBiomolecules2024

Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential.

Nicole R DeSouza, Kate J Nielsen, Tara Jarboe, Michelle Carnazza, Danielle Quaranto, Kaci Kopec, Robert Suriano, Humayun K Islam, Raj K Tiwari, Jan Geliebter

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. circRNAs in Endometrial Cancer-A Promising Biomarker: State of the Art.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicole R DeSouzaDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Kate J NielsenDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0009-0007-7845-2364
Tara JarboeDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Michelle CarnazzaDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Danielle QuarantoDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Kaci KopecDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0009-0008-9208-5836
Robert SurianoDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Humayun K IslamDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Raj K TiwariDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Jan GeliebterDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0000-0002-2944-7960
New York Medical College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly stable and operational RNA molecule. Dysregulated circRNA expression can drive carcinogenic and tumorigenic transformation through the orchestration of epigenetic modifications via extensive RNA and protein-binding domains. These multi-ranged functional capabilities have unveiled extensive identification of previously unknown molecular and cellular patterns of cancer cells. Reliable circRNA expression patterns can aid in early disease detection and provide criteria for genome-specific personalized medicine. Studies described in this review have revealed the novelty of circRNAs and their biological ss as prognostic and diagnostic biomarkers.

Indexed as

Biomarkers, TumorGene Expression Regulation, NeoplasticNeoplasmsRNA, CircularAnimalsEpigenesis, GeneticHumansBiomarkers, TumorRNA, CircularcancercircRNAcircRNA applicationcircRNA functioncircular RNAs

Identifiers

PMID38672402
PMCPMC11048371
OpenAlexW4393086405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.