Evidence map›Paper›PMID 38672233›Full record

ArticleBiomedicines2024

Expression of IMP3 and LIN28A RNA-Binding Proteins in Placentas of Patients with Pre-Eclampsia with and without Severe Features.

Maja Barbaric, Katarina Vukojevic, Anita Kolobaric, Martina Orlovic Vlaho, Tanja Kresic, Violeta Soljic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Maja BarbaricLaboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.ORCID 0000-0001-5874-9047
Katarina VukojevicDepartment of Anatomy, Histology and Embryology, School of Medicine, University of Split, 21000 Split, Croatia.ORCID 0000-0003-2182-2890
Anita KolobaricLaboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.ORCID 0000-0002-1361-8665
Martina Orlovic VlahoDepartment of Obstetrics, Gynecology University Clinical Hospital Mostar, 88000 Mostar, Bosnia and Herzegovina.ORCID 0000-0002-5337-0780
Tanja KresicDepartment of Obstetrics, Gynecology University Clinical Hospital Mostar, 88000 Mostar, Bosnia and Herzegovina.
Violeta SoljicLaboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.
University of Mostar · BAUniversity Clinical Hospital Mostar · BAUniversity of Split · HR

Funding

International Centre for Genetic Engineering and Biotechnology CRP/BIH18-03
6 · The paper itself

Abstract

backgroundthis study aimed to determine the expression of RNA-binding oncofetal proteins IMP3 and LIN28A in extravillous (EVT) and villous trophoblast (VT) cells of placentas from pre-eclamptic (PE) pregnancies to better understand the pathogenesis of PE.

methodsplacental tissue of 10 patients with PE with severe features, 10 patients with PE without severe features and 20 age-matched healthy pregnancy controls were analyzed by immunohistochemistry, double immunofluorescence and qPCR.

resultsWe found a decreased percentage of IMP3-positive EVT cells in PE with and without severe features compared to that of the healthy control (

conclusionsWe demonstrated that IMP3 expression is decreased in EVT and VT cells of placentas from pregnancies complicated with both PE with and without severe features. However, additional functional investigations are needed to clarify the role of IMP3 as a potential therapeutic target in the management of PE.

Indexed as

extravillous trophoblastIMP3LIN28Aplacentapre-eclampsia

Identifiers

PMID38672233
PMCPMC11048248
OpenAlexW4394837798

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.