Evidence map›Paper›PMID 38672106›Full record

ArticleBiomedicines2024

Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis.

Sasa Srsen, Martina Held, Mario Sestan, Nastasia Kifer, Ana Kozmar, Daniela Supe Domic, Benjamin Benzon, Alenka Gagro, Marijan Frkovic, Marija Jelusic

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Multi-omics characterization of Yao syndrome identifies three pathophysiological axes and disease-specific divergence from Blau syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  3. Biomarkers in Primary Systemic Vasculitides: Narrative Review.International journal of molecular sciences · 2026
    Review
  4. New avenues in childhood vasculitis.Pediatric rheumatology online journal · 2025
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sasa SrsenDepartment of Paediatrics, University Hospital Split, Spinciceva 1, 21000 Split, Croatia.ORCID 0000-0001-6555-2613
Martina HeldDepartment of Paediatrics, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.ORCID 0000-0002-4925-8948
Mario SestanDepartment of Paediatrics, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.ORCID 0000-0003-1092-6491
Nastasia KiferDepartment of Paediatrics, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Ana KozmarSchool of Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia.ORCID 0000-0002-6401-9558
Daniela Supe DomicDepartment of Medical Laboratory Diagnostic, University Hospital Split, Spinciceva 1, 21000 Split, Croatia.ORCID 0000-0002-5584-3182
Benjamin BenzonSchool of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.ORCID 0000-0003-3681-8499
Alenka GagroSchool of Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia.
Marijan FrkovicDepartment of Paediatrics, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.ORCID 0000-0002-1520-3375
Marija JelusicDepartment of Paediatrics, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.ORCID 0000-0002-1728-4260
University Hospital Centre Zagreb · HRUniversity of Split · HRUniversity of Zagreb · HR

Funding

Croatian Science Foundation IP-2019-04-8822
6 · The paper itself

Abstract

S100A8/A9 protein is a well-known marker of disease activity or severity in many autoimmune and autoinflammatory diseases, but there have not been many studies about the role of S100A8/A9 in IgA vasculitis (IgAV). The aim of our study was to evaluate S100A8/A9 as a possible biomarker of activity in IgAV. We measured the serum levels of S100A8/A9 in pediatric patients with IgA vasculitis at the onset of the disease, after three months, and after six months. We compared these levels between patients with active disease, remission, and a control group, and assessed their correlation with disease activity and other markers of inflammation. Patients with active disease had significantly higher levels of serum S100A8/A9 (median ± SD) than those in the control group at the beginning of the disease (5740 ± 3157 ng/mL vs. 1447 ± 858.3 ng/mL;

Indexed as

adolescentbiomarkerschildIgA vasculitisleukocyte L1 antigen complex

Identifiers

PMID38672106
PMCPMC11047888
OpenAlexW4393279732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.