Evidence map›Paper›PMID 38671924›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP

Sun Up Noh, Jinyeong Lim, Sung-Won Shin, Yeeun Kim, Woong-Yang Park, Ines Batinic-Haberle, Changhoon Choi, Won Park

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sun Up NohDepartment of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.ORCID 0000-0003-2091-8647
Jinyeong LimDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Republic of Korea.
Sung-Won ShinDepartment of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Yeeun KimDepartment of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Woong-Yang ParkDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Republic of Korea.ORCID 0000-0003-4234-0380
Ines Batinic-HaberleDepartment of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-8037-1861
Changhoon ChoiDepartment of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.ORCID 0000-0002-2847-1168
Won ParkDepartment of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Samsung Medical Center · KRSamsung (South Korea) · KRDuke University · US

Funding

National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) NRF-2019R1A2C2002304, NRF-2023R1A2C2003774
6 · The paper itself

Abstract

Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation. However, an in-depth understanding of intratumoral heterogeneity and immune pathways, as affected by Mn porphyrins, remains limited. Here, we explored the mechanisms underlying immunomodulation of a clinical candidate, MnTnBuOE-2-PyP

Indexed as

immune-based mechanisms underlying tumor radiosensitizationMnBuOE)Mn porphyrin clinical candidateMnTnBuOE-2-PyP5+ (BMX-001radiotherapysingle-cell RNA sequencingtumor heterogeneitytumor microenvironment

Identifiers

PMID38671924
PMCPMC11047573
OpenAlexW4394892290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.