Evidence map›Paper›PMID 38671864›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Long-Term Region-Specific Mitochondrial Functionality Changes in Both Cerebral Hemispheres after fMCAo Model of Ischemic Stroke.

Ksenija Lūcija Bahire, Reinis Maļuhins, Fiona Bello, Jolanta Upīte, Aleksandrs Makarovs, Baiba Jansone

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ksenija Lūcija BahireDepartment of Pharmacology, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Reinis MaļuhinsDepartment of Pharmacology, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Fiona BelloDepartment of Pharmacology, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Jolanta UpīteDepartment of Pharmacology, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Aleksandrs MakarovsDepartment of Pharmacology, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.
Baiba JansoneDepartment of Pharmacology, Faculty of Medicine, University of Latvia, LV-1586 Riga, Latvia.ORCID 0000-0002-4062-3363
University of Latvia · LV

Funding

ERA-NET Neuron consortium "Multi-scale investigation of synaptic dysfunction after stroke (MISST)" ES RTD/2018/29
6 · The paper itself

Abstract

Cerebral ischemia/reperfusion (I/R) refers to a secondary brain injury that results in mitochondrial dysfunction of variable extent, leading to neuronal cell damage. The impact of this process has mainly been studied in the short term, from the early hours up to one week after blood flow reperfusion, and in the ischemic hemisphere only. The focus of this study was to assess the long-term impacts of I/R on mitochondrial functionality using high-resolution fluorespirometry to evaluate state-dependent activities in both ischemic (ipsilateral) and non-ischemic (contralateral) hemispheres of male mice 60, 90, 120, and 180 days after I/R caused by 60-min-long filament-induced middle cerebral artery occlusion (fMCAo). Our results indicate that in cortical tissues, succinate-supported oxygen flux (Complex I&II OXPHOS state) and H

Indexed as

cerebral hemisphereshigh-resolution fluorespirometryischemia/reperfusion injurymiddle cerebral artery occlusionmitochondrial damageoxygen consumptionreactive oxygen species

Identifiers

PMID38671864
PMCPMC11047464
OpenAlexW4393931102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.