Evidence map›Paper›PMID 38671727›Full record

ArticleBioengineering (Basel, Switzerland)2024

Modeling the Effect of Annulus Fibrosus Stiffness on the Stressed State of a Vertebral L1 Body and Nucleus Pulposus.

Oleg Ardatov, Jolita Pachaleva, Viktorija Aleksiuk, Algirdas Maknickas, Ilona Uzieliene, Raminta Vaiciuleviciute, Eiva Bernotiene

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Oleg ArdatovFaculty of Mechanics, Vilnius Gediminas Technical University, LT-10223 Vilnius, Lithuania.ORCID 0000-0002-7221-3844
Jolita PachalevaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania.ORCID 0000-0001-8118-6377
Viktorija AleksiukDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania.ORCID 0000-0003-0175-4667
Algirdas MaknickasFaculty of Mechanics, Vilnius Gediminas Technical University, LT-10223 Vilnius, Lithuania.
Ilona UzielieneDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania.ORCID 0000-0001-5484-9163
Raminta VaiciuleviciuteDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania.ORCID 0000-0002-4315-7783
Eiva BernotieneDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania.
State Research Institute Centre for Innovative Medicine · LTVilnius Gediminas Technical University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The investigation examines the transference of stiffness from intervertebral discs (IVDs) to the lumbar body of the L1 vertebra and the interactions among adjacent tissues. A computational model of the vertebra was developed, considering parameters such as cortical bone thickness, trabecular bone elasticity, and the nonlinear response of the nucleus pulposus to external loading. A nonlinear dynamic analysis was performed, revealing certain trends: a heightened stiffness of the annulus fibrosus correlates with a significant reduction in the vertebral body's ability to withstand external loading. At a supplied displacement of 6 mm, the vertebra with a degenerative disc reached its yielding point, whereas the vertebrae with a healthy annulus fibrosus exhibited a strength capacity exceeding 20%. The obtained findings and proposed methodology are potentially useful for biomedical engineers and clinical specialists in evaluating the condition of the annulus fibrosus and predicting its influence on the bone components of the spinal system.

Indexed as

annulus fibrosusfinite element methodhyperelasticityintervertebral discnucleus pulposusstiffnessvertebra

Identifiers

PMID38671727
PMCPMC11047532
OpenAlexW4393146472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.