Evidence map›Paper›PMID 38671716›Full record

ReviewChildren (Basel, Switzerland)2024

Silver Diamine Fluoride in Pediatric Dentistry: Effectiveness in Preventing and Arresting Dental Caries-A Systematic Review.

Alexandrina Muntean, Soundouss Myriam Mzoughi, Mariana Pacurar, Sebastian Candrea, Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Laura Ferrante, Gianna Dipalma, Francesco Inchingolo, Andrea Palermo and 1 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07741409 (Povidone Iodine to Prevent Early Childhood Caries), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07741409 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Povidone Iodine to Prevent Early Childhood Caries

TypeinterventionalSponsorJeffrey A. BanasRan2026 to 2028Enrolled174ConditionsDental CariesArmsPovidone Iodine 5% Soln,Top,Kit, Probiotics, Placebo
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Clinical decision-making in pulp therapy of primary teeth among Tunisian dental practitioners: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
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  4. Article
  5. Knowledge, attitude and practice of paediatric dentists towards silver diammine fluoride in Egypt: a national survey.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexandrina MunteanDepartment of Paediatric Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 31 A. Iancu Street, 400083 Cluj-Napoca, Romania.ORCID 0000-0002-3960-6910
Soundouss Myriam MzoughiDepartment of Paediatric Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 31 A. Iancu Street, 400083 Cluj-Napoca, Romania.ORCID 0009-0004-5189-5913
Mariana PacurarDepartment of Orthodontics, Faculty of Dental Medicine, University of Medicine, Pharmacy Science and Technology "G. E. Palade" Targu Mures Romania, Gheorghe Marinescu Street, nr. 38, 540139 Târgu Mureș, Romania.
Sebastian CandreaDepartment of Paediatric Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 31 A. Iancu Street, 400083 Cluj-Napoca, Romania.
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Laura FerranteDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Andrea PalermoCollege of Medicine and Dentistry, Birmingham B4 6BN, UK.ORCID 0000-0002-3288-490X
Ioana Roxana BordeaDepartment of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 15 V. Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7166-9949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTooth decay is considered a global scourge by the World Health Organization (WHO) starting at an early age. In recent years, silver diamine fluoride (SDF) has regained interest, particularly in pediatric dentistry, used to prevent the development of carious lesions or arrest their progression.

objectiveThe aim of this study was to assess, through a systematic review of the literature, the effectiveness of SDF, used in pedodontics, in temporary teeth, in preventing or arresting dental caries. MATERIAL AND

methodsAn electronic search was conducted on PubMed, Web of Science and Scopus. The effect of SDF on both temporary and permanent teeth has been considered.

resultsThe inclusion criteria identified 16 randomized controlled trials involving patients aged 18 months to 13 years and followed over a period of 12-30 months.

conclusionsSDF is a practical, accessible and effective non-invasive way to prevent and arrest caries in temporary and permanent teeth. Its application requires regular monitoring. The resulting black spot is diminished by immediate application of potassium iodide but this may affect its effectiveness.

Indexed as

caries arrestcariostatic agentsdental cariespediatric dentistrypreventionsilver diamine fluoride

Identifiers

PMID38671716
PMCPMC11049537

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.