ArticleChildren (Basel, Switzerland)2024
Serum Biomarker Analysis in Pediatric ADHD: Implications of Homocysteine, Vitamin B12, Vitamin D, Ferritin, and Iron Levels.
Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pooled it
- Vitamin D +Docosahexaenoic acid supplementation: effects on serum markers and symptoms in ADHD children.American journal of translational research · 2026Article
- Assessing the Impact of Serum Ferritin on Life Skills in Children with ADHD.Children (Basel, Switzerland) · 2025Article
- Biomarkers and Neuropsychological Tools in Attention-Deficit/Hyperactivity Disorder: From Subjectivity to Precision Diagnosis.Medicina (Kaunas, Lithuania) · 2025Review
- Gut-Brain Inflammatory Pathways in Attention-Deficit/Hyperactivity Disorder: The Role and Therapeutic Potential of Diet.Metabolites · 2025Review
- Machine Learning Based Early Diagnosis of ADHD with SHAP Value Interpretation: A Retrospective Observational Study.Neuropsychiatric disease and treatment · 2025Article
- Prevention of anemia in children through the consumption of a blueberry and quinoa drink enriched with iron as part of a nutritional program.Frontiers in nutrition · 2025Article
- Exploring the levels of homocysteine and its relationship with cognitive function in children with attention deficit hyperactivity disorder.Frontiers in neurology · 2025Article
- Nutritional management and autism spectrum disorder: A systematic review.World journal of clinical pediatrics · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current diagnosis of attention deficit hyperactivity disorder (ADHD) is based on history, clinical observation, and behavioral tests. There is a high demand to find biomarkers for the diagnosis of ADHD. The aim of this study is to analyze the serum profiles of several biomarkers, including homocysteine (Hcy), vitamin B12, vitamin D, ferritin, and iron, in a cohort of 133 male subjects (6.5-12.5 years), including 67 individuals with an ADHD diagnosis based on DSM-V criteria and 66 age-matched healthy boys (healthy controls, HC). Assessments for ADHD included the Iowa Conners' Teacher Rating Scale (CPRS) and the ADHDT test, as well as cognitive assessments using the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the TROG-2 language comprehension test. Hcy and iron were quantified using spectrophotometry, while vitamin B12 and total 25-hydroxy vitamin D levels were determined using an electrochemiluminescence immunoassay (ECLIA) and ferritin was measured using a particle-enhanced immunoturbidimetric assay. The results showed significantly increased Hcy levels and decreased vitamin B12 levels in ADHD patients compared to HCs. Multiple logistic regression analysis indicated that Hcy is a potential prognostic indicator for ADHD. These results suggest that elevated homocysteine and decreased vitamin B12 may serve as markers for the diagnosis and prognosis of ADHD.
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