Evidence map›Paper›PMID 38671669›Full record

ArticleChildren (Basel, Switzerland)2024

Egyptian Pediatric Guidelines for the Management of Children with Isolated Thrombocytopenia Using the Adapted ADAPTE Methodology-A Limited-Resource Country Perspective.

Galila Mokhtar, Ashraf Abdelbaky, Amira Adly, Dina Ezzat, Gehan Abdel Hakeem, Hoda Hassab, Ilham Youssry, Iman Ragab, Laila M Sherief, Marwa Zakaria and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 5 countries.

Galila MokhtarPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo 11566, Egypt.
Ashraf AbdelbakyPediatric Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Amira AdlyPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo 11566, Egypt.
Dina EzzatPediatric Hematology Unit, Pediatric Department, Beni-Suef University, Beni-Suef 62521, Egypt.ORCID 0000-0002-4835-2465
Gehan Abdel HakeemPediatric Hematology and Oncology Unit, Pediatric Department, Minia University, Minia 61519, Egypt.ORCID 0000-0002-0009-2465
Hoda HassabPediatric Hematology and Oncology Unit, Pediatric Department, Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt.
Ilham YoussryPediatric Hematology and Bone Marrow Transplantation Unit, Pediatric Department, Cairo University, Giza 12613, Egypt.ORCID 0000-0001-5972-7712
Iman RagabPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-5848-8294
Laila M SheriefPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig 44519, Egypt.
Marwa ZakariaPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig 44519, Egypt.
Mervat HeshamPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig 44519, Egypt.
Niveen SalamaPediatric Hematology and Bone Marrow Transplantation Unit, Pediatric Department, Cairo University, Giza 12613, Egypt.
Nouran SalahPediatric Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0001-6507-8835
Rasha A A AfifiPediatric Hematology and Bone Marrow Transplantation Unit, Pediatric Department, Cairo University, Giza 12613, Egypt.
Rasha El-AshryPediatric Hematology and Oncology Unit, Pediatric Department, Mansoura University, Mansoura 35516, Egypt.
Sara MakkeyahPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-3649-5725
Sonia AdolfPediatric, Hematology Department, Institute of Medical Research and Clinical Studies, National Research Center, Giza 1770, Egypt.
Yasser S AmerPediatrics Department, Quality Management Department, King Saud University Medical City, Riyadh 11451, Saudi Arabia.
Tarek E I OmarPediatrics Department, Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt.
James BusselPediatrics Department, Well Cornell Medical College, New York, NY 10065, USA.
Eman Abd El RaoufPediatric Hematology and Bone Marrow Transplantation Unit, Pediatric Department, Cairo University, Giza 12613, Egypt.
Mervat AtfyPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig 44519, Egypt.
Mohamed EllaboudyPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo 11566, Egypt.
Ivan FlorezDepartment of Pediatrics, University of Antioquia, Medellin 050010, Colombia.
Ain Shams University · EGCairo University · EGZagazig University · EGAlexandria University · EGBeni-Suef University · EGCornell University · USMansoura University · EGMinia University · EGResearch Institute of Ophthalmology · EGUniversidad de Antioquia · COUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombocytopenia is a prevalent presentation in childhood with a broad spectrum of etiologies, associated findings, and clinical outcomes. Establishing the cause of thrombocytopenia and its proper management have obvious clinical repercussions but may be challenging. This article provides an adaptation of the high-quality Clinical Practice Guidelines (CPGs) of pediatric thrombocytopenia management to suit Egypt's health care context.

methodsThe Adapted ADAPTE methodology was used to identify the high-quality CPGs published between 2010 and 2020. An expert panel screened, assessed and reviewed the CPGs and formulated the adapted consensus recommendations based on the best available evidence. DISCUSSION: The final CPG document provides consensus recommendations and implementation tools on the management of isolated thrombocytopenia in children and adolescents in Egypt. There is a scarcity of evidence to support recommendations for various management protocols. In general, complete clinical assessment, full blood count, and expert analysis of the peripheral blood smear are indicated at initial diagnosis to confirm a bleeding disorder, exclude secondary causes of thrombocytopenia and choose the type of work up required. The International Society of Hemostasis and thrombosis-Bleeding assessment tool (ISTH-SCC BAT) could be used for initial screening of bleeding manifestations. The diagnosis of immune thrombocytopenic purpura (ITP) is based principally on the exclusion of other causes of isolated thrombocytopenia. Future research should report the outcome of this adapted guideline and include cost-analysis evaluations.

Indexed as

bleedingisolated thrombocytopeniapediatric

Identifiers

PMID38671669
PMCPMC11048986
OpenAlexW4394612032

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.