Evidence map›Paper›PMID 38671666›Full record

ArticleChildren (Basel, Switzerland)2024

Study on Nocturnal Infant Crying Evaluation (NICE) and Reflux Disease (RED).

Greta Carabelli, Ivan Binotto, Chiara Armano, Lorenza Bertù, Chiara Luini, Luana Nosetti, Massimo Agosti, Silvia Salvatore

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Greta CarabelliPediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
Ivan BinottoPediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
Chiara ArmanoPediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
Lorenza BertùResearch Center Tromboembolic Diseases, University of Insubria, 21100 Varese, Italy.
Chiara LuiniPediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
Luana NosettiPediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-5453-724X
Massimo AgostiPediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
Silvia SalvatorePediatric Department, "F. Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy.
University of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNocturnal infant crying is often empirically treated with acid suppressants. The aim of this study was to evaluate the prevalence and characteristics of gastroesophageal reflux (GER) in infants with unexplained persistent crying.

methodsWe enrolled all infants (0-12 months) referred for suspected GER disease who underwent esophageal impedance-pH monitoring (MII-pH) for unexplained persistent crying not improved by parental reassurance, dietary modification or alginate. Gastrointestinal malformation/surgery, neurological impairment and infections were exclusion criteria. Demographic and anthropometric parameters, GER symptoms and questionnaires (I-GERQ-R) and MII-pH data were recorded and analyzed. Normal MII-pH was defined when acid exposure was <3%, symptom index was <50% and symptom association probability was <95%. Acid exposure >5% and >10% was also considered. Statistical analysis was performed using Chi-Square and univariate and multivariable regression analysis.

resultsWe included 50 infants (median age 3.5 months) who fulfilled the study criteria: 30 (60%) had normal MII-pH. I-GERQ-R score was abnormal in 33 (66%) infants, and 21/33 (64%) had normal MII-pH (

conclusionsInfants with persistent unexplained and nocturnal crying should not be empirically treated with acid inhibitors.

Indexed as

acid suppressantcryingdistressesophageal impedance–pH monitoringgastroesophageal refluxinfantMII-pHproton pump inhibitorsregurgitationsleep

Identifiers

PMID38671666
PMCPMC11048841
OpenAlexW4394580661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.