ArticleScandinavian journal of medicine & science in sports2024
Physical activity alters the effect of genetic determinants of adiposity on hypertension among individuals of European ancestry in the UKB.
Article in Scandinavian journal of medicine & science in sports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- The association between physical activity and metabolic dysfunction-associated steatotic liver disease: Evidence from the National Health and Nutrition Examination Survey and UK Biobank.The Journal of international medical research · 2026Article
- From early smoking to COPD and other chronic respiratory disease: unraveling the roles of chemical pollutants and underlying toxicological mechanisms.BMC pulmonary medicine · 2026Article
- Physical Activity and Favorable Adiposity Genetic Liability Reduce the Risk of Hypertension Among High Body Mass Individuals.Journal of the American Heart Association · 2025Article
- Physical activity alters the effect of genetic determinants of adiposity on hypertension among individuals of European ancestry in the UKB.Scandinavian journal of medicine & science in sports · 2024Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Hypertension is a leading risk factor for cardiovascular disease and is modulated by genetic variants. This study aimed to assess the effect of obesity genetic liability and physical activity on hypertension among European and African ancestry individuals within the UK Biobank (UKB). Participants were 230 115 individuals of European ancestry and 3239 individuals of African ancestry from UKB. Genetic liability for obesity were estimated using previously published data including genetic variants and effect sizes for body mass index (BMI), waist-hip ratio (WHR) and waist circumference (WC) using Plink software. The outcome was defined as stage 2 hypertension (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥90 mmHg, or the use of anti-hypertensive medications). The association between obesity genetic liability and the outcome was assessed across categories of self-reported physical activity using logistic regression. Among European ancestry participants, there was up to a 1.2 greater odds of hypertension in individuals with high genetic liability and low physical activity compared to individuals with low genetic liability and high physical activity (p < 0.001). In individuals engaging in low levels of physical activity compared with moderate/high physical activity, the effect of BMI genetic liability on hypertension was greater (p
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Registered trials
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