Evidence map›Paper›PMID 38671541›Full record

ArticleJournal of cannabis research2024

Investigating sex differences and age of onset in emotion regulation, executive functioning, and cannabis use in adolescents and young adults.

Natasha E Wade, Kelly E Courtney, Alexander L Wallace, Laura Hatz, Joanna Jacobus

Abstract read
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In one paragraph

Article in Journal of cannabis research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natasha E WadeDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.
Kelly E CourtneyDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.
Alexander L WallaceDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.
Laura HatzDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.
Joanna JacobusDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. jjacobus@ucsd.edu.

Funding

Alcohol Research in the Science/Practitioner ModelT32AA013525 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY, ANDREA SPADONI TOWNSEND · 2002 to 2026
$8.4M
Cannabis and Nicotine Co-Use Influences on Protracted Development of Neural Structure and FunctionR01DA054106 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus · 2021 to 2026
$3.2M
Cannabis Toxicology in Relation to Neurocognitive Outcomes in AdolescentsK08DA050779 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WADE, NATASHA E · 2021 to 2025
$957k
NIAAA NIH HHS T32 AA013525NIDA NIH HHS K08 DA050779NIDA NIH HHS R01 DA054106 and R21 DA047953
6 · The paper itself

Abstract

backgroundYoung adults have historically high levels of cannabis use at a time which coincides with emotional and cognitive development. Age of regular onset of cannabis use and sex at birth are hypothesized to influence the relationship between cannabis use and cognition. Here we investigated past 6-month cannabis use in relation to emotional and executive functioning. We further considered age of onset and sex in subgroup analyses.

methodYoung adults (N = 225; ages 16-22) completed a substance use interview and cognitive battery, including the Emotional Word-Emotional Face Stroop and NIH toolbox executive functioning tasks. Linear regressions examined relationships between past 6-month cannabis use episodes and performance. Subgroup analyses investigated whether age of onset or sex impacted relationships.

resultsAfter correcting for multiple comparisons, greater past 6-month cannabis use episodes were related to poorer Emotional Stroop Congruent Accuracy (p = .0004, FDR-p = .002) and List Sorting Working Memory (p = .02, FDR-p = .10) performance. Younger age of regular use onset marginally related to lower Emotional Stroop Congruent Accuracy performance (p = .03, FDR-p = .13). There were no cannabis use by sex interactions on cognition.

conclusionsConsistent with prior findings, results suggest small reductions in cannabis-related performance in processing speed during emotional Stroop and working memory tasks. Age of onset was modestly related to Stroop performance, but not sex. Longitudinal studies which detail patterns of cannabis and other substance use are needed to better assess brain-behavior relationships and other factors (e.g., age of onset of regular use, sex) which could influence cannabis-related impairments in cognitive functioning.

Indexed as

Age of onsetCannabisEmotional functioningExecutive functioningSex

Identifiers

PMID38671541
PMCPMC11046960

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.