Evidence map›Paper›PMID 38671377›Full record

ArticleBMC pregnancy and childbirth2024

Urogenital cultures and preterm birth in women with cervical cerclage: a single center retrospective cohort study.

Evelien Seys, Ann-Sophie Page, Jan Deprest, Lore Lannoo, Kristel van Calsteren, Roland Devlieger, Johannes van der Merwe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Evelien SeysDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Ann-Sophie PageDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Jan DeprestDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Lore LannooDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Kristel van CalsterenDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Roland DevliegerDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Johannes van der MerweDepartment of Obstetrics and Gynecology, Division Woman and Child, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium. hannes.vandermerwe@uzleuven.be.
KU Leuven · BE

Funding

Fonds Wetenschappelijk Onderzoek 1803311N
6 · The paper itself

Abstract

backgroundThe leading hypothesis of the pathogenesis of cervical insufficiency suggests a role of cervical inflammation. Urogenital tract infections could play a causative role in this process. To test this hypothesis in women with a cervical cerclage, we aimed to retrospectively examine the relationship between gestational age (GA) at delivery and positive urogenital cultures.

methodsThis single center retrospective study reviewed the records of all women with a singleton pregnancy that underwent cervical cerclage (n = 203) between 2010 and 2020 at the University Hospital of Leuven, Belgium. Transvaginal cerclages were categorized as history indicated (TVC I, n = 94), ultrasound indicated (TVC II, n = 79) and clinically indicated (TVC III, n = 20). Additionally, ten women received transabdominal cerclage (TAC). Urogenital cultures (vaginal and urine) were taken before and after cerclage with 4-week intervals. Urogenital cultures were reported 'positive' if urine and/or vaginal cultures showed significant growth of a microorganism. Treatment decision depended on culture growth and clinical presentation. The primary aim was to evaluate the association between the urogenital culture results and the GA at delivery, for each of the cerclage groups. Secondarily, to investigate the effect of antibiotic treatment of positive cultures on GA at delivery.

resultsPositive pre-cerclage urogenital cultures were associated with lower GA at delivery in TVC III (positive culture 26w4d ± 40d vs. negative 29w6d ± 54d, p = 0.036). For TVC I, GA at delivery was longer when pre-cerclage urogenital cultures were positive (positive culture 38w0d ± 26d vs. negative 35w4d ± 42d, p = 0.035). Overall post-cerclage urogenital cultures status was not associated with a different GA at delivery. Treating patients with pre- or post-cerclage positive urogenital cultures did also not change GA at delivery.

conclusionPositive urogenital cultures taken before clinically indicated cerclage intervention may be associated with lower GA at delivery. However, there seems to be no benefit of antibiotic treatment or routine urogenital cultures during follow-up of asymptomatic women after cerclage placement.

Indexed as

Cerclage, CervicalGestational AgePremature BirthVaginaAdultBelgiumFemaleHumansPregnancyRetrospective StudiesUrinary Tract InfectionsUterine Cervical IncompetenceCervical cerclagePreterm birthUrine cultureVaginal culture

Identifiers

PMID38671377
PMCPMC11046802
OpenAlexW4395668309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.