Evidence map›Paper›PMID 38671372›Full record

ArticleBMC anesthesiology2024

Predictive value of S100B and brain derived neurotrophic factor for radiofrequency treatment of lumbar disc prolapse.

Wael Fathy, Mona Hussein, Rehab Magdy, Hatem Elmoutaz, Neveen A Youssef, Marwa F Abd Alla, Ahmed M El Shaarawy, Mohamed Abdelbadie

Abstract read
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In one paragraph

Article in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wael FathyDepartment of Anesthesiology, Surgical ICU and Pain Management, Beni-Suef University, Salah Salem Street, Beni-Suef, 62511, Egypt. drwaelfathy@med.bsu.edu.eg.ORCID 0000-0002-6971-113X
Mona HusseinDepartment of Neurology, Beni-Suef University, Beni-Suef, Egypt.
Rehab MagdyDepartment of Neurology, Cairo University, Cairo, Egypt.
Hatem ElmoutazDepartment of Anesthesiology, Surgical ICU and Pain Management, Beni-Suef University, Salah Salem Street, Beni-Suef, 62511, Egypt.
Neveen A YoussefDepartment of Clinical and Chemical Pathology, Beni-Suef University, Beni-Suef, Egypt.
Marwa F Abd AllaDepartment of Medical Biochemistry and Molecular Biology, Beni Suef University, Beni-Suef, Egypt.
Ahmed M El ShaarawyDepartment of Anesthesiology, Surgical ICU and Pain Management, Beni-Suef University, Salah Salem Street, Beni-Suef, 62511, Egypt.
Mohamed AbdelbadieDepartment of Anesthesiology, Surgical ICU and Pain Management, Beni-Suef University, Salah Salem Street, Beni-Suef, 62511, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis work aimed to analyze serum S100B levels and brain-derived neurotrophic factor (BDNF) in patients with lumbar disc prolapse to test their predictive values concerning the therapeutic efficacy of pulsed radiofrequency.

methodsThis prospective interventional study was carried out on 50 patients candidates for radiofrequency for treating symptomatic lumbar disc prolapse. Pain severity and functional disability were assessed using the Numeric Rating Scale (NRS) and Functional rating index (FRI) before as well as two weeks, 1, 3, and 6 months after the radiofrequency. Quantitative assessment of serum S100B level and BDNF was done for all the included patients one day before radiofrequency.

resultsThe scores of NRS and FRI were significantly improved at two weeks, 1, 3, and 6 months following radiofrequency (P-value < 0.001 in all comparisons). Statistically significant positive correlations were found between duration of pain, NRS, and S100B serum level before radiofrequency, and both NRS (P-value = 0.001, 0.035, < 0.001 respectively) and FRI (P-value = < 0.001, 0.009, 0.001 respectively) 6 months following radiofrequency. Whereas there were statistically significant negative correlations between BDNF serum level before radiofrequency and both NRS and FRI 6 months following radiofrequency (P-value = 0.022, 0.041 respectively). NRS and S100B serum levels before radiofrequency were found to be independent predictors of NRS 6 months following radiofrequency (P-value = 0.040. <0.001, respectively).

conclusionSerum level of S100B is a promising biomarker that can predict functional outcomes after pulsed radiofrequency in patients with lumbar disc prolapse.

Indexed as

Brain-Derived Neurotrophic FactorIntervertebral Disc DisplacementLumbar VertebraePredictive Value of TestsS100 Calcium Binding Protein beta SubunitAdultBiomarkersFemaleHumansMaleMiddle AgedPain MeasurementProspective StudiesPulsed Radiofrequency TreatmentTreatment OutcomeBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorS100B protein, humanS100 Calcium Binding Protein beta SubunitBDNFFRILumbar disc prolapseNRSPulsed radiofrequencyS100B

Identifiers

PMID38671372
PMCPMC11046968

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.