Evidence map›Paper›PMID 38671329›Full record

ArticleMolecular neurobiology2024

Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD.

Adam Lee, Paul Thuras, Joshua Baller, Chuan Jiao, Bin Guo, Christopher R Erbes, Melissa A Polusny, Chunyu Liu, Baolin Wu, Kelvin O Lim and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Neurobiology of stress · 2025
    Review
  5. Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Adam LeeDepartment of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Room 7-115 Weaver-Densford Hall, 308 Harvard St SE, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-8311-581X
Paul ThurasDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-0888-3074
Joshua BallerMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3936-7953
Chuan JiaoDepartment of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0002-8921-7841
Bin GuoDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-9124-1955
Christopher R ErbesDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Melissa A PolusnyDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-4932-305X
Chunyu LiuDepartment of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0002-5986-4415
Baolin WuDepartment of Epidemiology and Biostatistics, Program in Public Health, University of California-Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-6676-0422
Kelvin O LimDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2390-7268
Jeffrey R BishopDepartment of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Room 7-115 Weaver-Densford Hall, 308 Harvard St SE, Minneapolis, MN, 55455, USA. jrbishop@umn.edu.ORCID http://orcid.org/0000-0001-7653-8980
University of Minnesota · USMinneapolis VA Health Care System · USGeriatric Research Education and Clinical Center · USInserm · FRSUNY Upstate Medical University · USUniversity of California, Irvine · US

Funding

Epigenetics of PTSD Treatment ResponseR21AT009475 · NCCIH · UNIVERSITY OF MINNESOTA · PI BISHOP, JEFFREY R · 2018 to 2019
$422k
NCCIH NIH HHS R21AT009475U.S. Department of Veterans Affairs 5I01CX000683-01
6 · The paper itself

Abstract

Meditation-based interventions are novel and effective non-pharmacologic treatments for veterans with PTSD. We examined relationships between treatment response, early life trauma exposure, DNA polymorphisms, and methylation in the serotonin transporter (SLC6A4) and FK506-binding protein 5 (FKBP5) genes. DNA samples and clinical outcomes were examined in 72 veterans with PTSD who received meditation-based therapy in two separate studies of mindfulness-based stress reduction (MBSR) and Transcendental Meditation (TM). The PTSD Checklist was administered to assess symptoms at baseline and after 9 weeks of meditation intervention. We examined the SLC6A4 promoter (5HTTLPR_L/S insertion/deletion + rs25531_A/G) polymorphisms according to previously defined gene expression groups, and the FKBP5 variant rs1360780 previously associated with PTSD disease risk. Methylation for CpG sites of SLC6A4 (28 sites) and FKBP5 (45 sites) genes was quantified in DNA samples collected before and after treatment. The 5HTTLPR L

Indexed as

DNA MethylationMeditationSerotonin Plasma Membrane Transport ProteinsStress Disorders, Post-TraumaticTacrolimus Binding ProteinsVeteransAdultFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticTacrolimus Binding Protein 5Treatment OutcomeSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanTacrolimus Binding Protein 5Tacrolimus Binding ProteinsFK506-binding protein 5 (FKBP5)Hypothalamic–pituitary adrenal (HPA) axisMindfulness-Based Stress ReductionPosttraumatic stress disorderSerotonin transporter (SLC6A4)Transcendental Meditation

Identifiers

PMID38671329
OpenAlexW4395694482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.