ArticleNature immunology2024
Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- ApolipoproteinEiScience · 2026Article
- Myeloid cell reprogramming drives enhanced defense againstProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities.MedComm · 2026Review
- Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition.Journal of advanced research · 2026Article
- Pulmonary Delivery of Self-Amplifying RNA: Balancing Inflammation and Durable Transgene Expression.ACS nano · 2026Article
- β-glucan elicits APOE-dependent peripheral trained immunity to suppress hepatocellular carcinoma.Journal for immunotherapy of cancer · 2026Article
- Beyond Infection-Indoor Airborne Pathogens as Contributors to Respiratory Inflammation and Immune Dysregulation: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Alveolar macrophages undergo postnatal transition from a hyperphagocytic and proinflammatory profile to a tolerogenic profile.iScience · 2026Article
- Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.Bioactive materials · 2026Article
- Pollutant particles enhance house dust mite induced type 2 inflammation and the recruitment of monocyte derived Cd11cParticle and fibre toxicology · 2026Article
- Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes.The Journal of experimental medicine · 2026Article
- TAF15 promotes the healing of diabetic foot ulcers by mediating the transcriptional activation of APOE through CEBPB to regulate PTX3.Molecular genetics and genomics : MGG · 2026Article
- Recent perspectives on macrophage memory: types, mechanisms, and characteristics in pulmonary diseases.Cell communication and signaling : CCS · 2026Review
- IL-6 regulates the polarization of Dectin-1 macrophages to weaken immune escape in thyroid cancer.Journal of translational medicine · 2026Article
- Trained immunity and related memory responses in lung health and disease.Frontiers in immunology · 2026Review
- Integrative bioinformatics analysis identifies APOE as a candidate link between lipid dysregulation and macrophage activation in inborn errors of metabolism.Frontiers in pharmacology · 2026Article
- Predictive lipidaemic and clinical factors for PVR formation after RRD surgery in nondiabetic patients.International journal of ophthalmology · 2026Article
- Decoding macrophage heterogeneity in the pulmonary fibrosis lung cancer transition.Frontiers in immunology · 2026Review
- Decreased expression of immune activator WARS1 and other pro-inflammatory mediators in type 1-like macrophages as an associated mode of action in response to fucoidan from marine brown algae.Frontiers in immunology · 2026Article
- Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy.Nature communications · 2025Article
Corrections and comments
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Authors and funding
32 authors at 12 institutions in 6 countries.
H Theobald *Quantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-4580-5542
D A Bejarano *Quantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-7804-0131
N Katzmarski *Quantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
J Haub *Quantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
J Schulte-SchreppingGenomics & Immunoregulation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
J YuQuantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
K BasslerGenomics & Immunoregulation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-4780-372X
A L AmentUniversity of Bonn, Transdisciplinary Research Area Life and Health, Organoid Biology, Life & Medical Sciences Institute, Bonn, Germany.
C Osei-SarpongImmunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, Germany.
F PiattiniInstitute of Molecular Health Science, Department of Biology, ETH Zürich, Zürich, Switzerland.
L VornholzInstitute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich, Germany.
W T'JonckCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, Edinburgh, UK.
A H GyörfiDepartment of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Germany.
H HayerQuantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
X YuInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
S SheoranQuantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
A Al JawaznehI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
S ChakarovShanghai Institute of Immunology, Shanghai JiaoTong School of Medicine, Shanghai, China.
K HaendlerPRECISE Platform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn and West German Genome Center, Bonn, Germany.
G D BrownMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0002-0287-5383
D L WilliamsDepartment of Surgery and Center for Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
L BosurgiI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J H W DistlerDepartment of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Germany.
F GinhouxShanghai Institute of Immunology, Shanghai JiaoTong School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-2857-7755
J RulandInstitute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-8381-3597
M D BeyerImmunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, Germany.ORCID http://orcid.org/0000-0001-9704-148X
M GreterInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-7220-5369
C C BainCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8884-327X
A I Vazquez-ArmendarizUniversity of Bonn, Transdisciplinary Research Area Life and Health, Organoid Biology, Life & Medical Sciences Institute, Bonn, Germany.
M KopfInstitute of Molecular Health Science, Department of Biology, ETH Zürich, Zürich, Switzerland.
J L SchultzeGenomics & Immunoregulation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2812-9853
A SchlitzerQuantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany. andreas.schlitzer@uni-bonn.de.ORCID http://orcid.org/0000-0001-7662-3712
University of Bonn · DECentre for Inflammation Research · GBDüsseldorf University Hospital · DEETH Zurich · CHUniversität Hamburg · DEUniversity of Zurich · CHAgency for Science, Technology and Research · SGEast Tennessee State University · USGerman Center for Infection Research · DEGerman Center for Neurodegenerative Diseases · DETechnical University of Munich · DEUniversity of Exeter · GB
Funding
Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6MInnate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8MDevelopment of an alpha-1 phosphate mannan vaccine against the emerging fungal pathogen Candida auris.R21AI173607 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI WILLIAMS, DAVID L. · 2023 to 2024
$413kMedical Research Council MR/V033417/1NIAID NIH HHS R21 AI173607NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197Wellcome Trust
Abstract
The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and developmental adaptation remain elusive. To reveal such mechanisms, we developed a reductionist model of environmental intranasal β-glucan exposure, allowing for the detailed interrogation of molecular mechanisms of pulmonary macrophage adaptation. Employing single-cell transcriptomics, high-dimensional imaging and flow cytometric characterization paired with in vivo and ex vivo challenge models, we reveal that pulmonary low-grade inflammation results in the development of apolipoprotein E (ApoE)-dependent monocyte-derived alveolar macrophages (ApoE
Indexed as
Apolipoproteins Ebeta-GlucansLectins, C-TypeMacrophages, AlveolarMice, Inbred C57BLAdaptation, PhysiologicalAnimalsCD11b AntigenCell DifferentiationDectin-1LungMiceMice, KnockoutMonocytesApoe protein, mouseApolipoproteins Ebeta-GlucansCD11b AntigenDectin-1Lectins, C-Type
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.