Evidence map›Paper›PMID 38671227›Full record

ArticleScientific reports2024

Dysregulation of TCONS_00006091 contributes to the elevated risk of oral squamous cell carcinoma by upregulating SNAI1, IRS and HMGA2.

Danhua Ma, Jijun Chen, Yuyuan Shi, Hongyan Gao, Zhen Wei, Jiayan Fan, Liang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danhua MaDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China.
Jijun ChenDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China.
Yuyuan ShiDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China.
Hongyan GaoDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China.
Zhen WeiDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China.
Jiayan FanDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China.
Liang WangDepartment of Stomatology, Ningbo No. 2 Hospital, No. 41 Northwest Street, Ningbo, 315010, Zhejiang, China. mdh7639@163.com.
Ningbo No. 2 Hospital · CN

Funding

Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province 2019E10020Medical Scientific Research Foundation of Zhejiang Province 2021KY297Project of Ningbo Leading Medical & Health Discipline 2022-F20
6 · The paper itself

Abstract

In this study, we aimed to study the role of TCONS_00006091 in the pathogenesis of oral squamous cellular carcinoma (OSCC) transformed from oral lichen planus (OLP). This study recruited 108 OSCC patients which transformed from OLP as the OSCC group and 102 OLP patients with no sign of OSCC as the Control group. ROC curves were plotted to measure the diagnostic values of TCONS_00006091, miR-153, miR-370 and let-7g, and the changes in gene expressions were measured by RT-qPCR. Sequence analysis and luciferase assays were performed to analyze the molecular relationships among these genes. Cell proliferation and apoptosis were observed via MTT and FCM. TCONS_00006091 exhibited a better diagnosis value for OSCC transformed from OLP. OSCC group showed increased TCONS_00006091 expression and decreased expressions of miR-153, miR-370 and let-7g. The levels of SNAI1, IRS and HMGA2 was all significantly increased in OSCC patients. And TCONS_00006091 was found to sponge miR-153, miR-370 and let-7g, while these miRNAs were respectively found to targe SNAI1, IRS and HMGA2. The elevated TCONS_00006091 suppressed the expressions of miR-153, miR-370 and let-7g, leading to the increased expression of SNAI1, IRS and HMGA2. Also, promoted cell proliferation and suppressed apoptosis were observed upon the over-expression of TCONS_00006091. This study demonstrated that the expressions of miR-153, miR-370 and let-7g were down-regulated by the highly expressed TCONS_00006091 in OSCC patients, which accordingly up-regulated the expressions of SNAI1, IRS and HMGA2, resulting in the promoted cell proliferation and suppressed cell apoptosis.

Indexed as

ApoptosisCarcinoma, Squamous CellCell ProliferationGene Expression Regulation, NeoplasticHMGA2 ProteinMicroRNAsMouth NeoplasmsSnail Family Transcription FactorsCell Line, TumorFemaleHumansLichen Planus, OralMaleMiddle AgedUp-RegulationHMGA2 ProteinHMGA2 protein, humanMicroRNAsSNAI1 protein, humanSnail Family Transcription FactorsHMGA2IRSlncRNAOral squamous cellular carcinomaProliferationSNAI1

Identifiers

PMID38671227
PMCPMC11053020
OpenAlexW4395675588

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.