Evidence map›Paper›PMID 38671050›Full record

ArticleNature nanotechnology2024

Self-assembly of peptide nanocapsules by a solvent concentration gradient.

Haopeng Li, Xuliang Qian, Harini Mohanram, Xiao Han, Huitang Qi, Guijin Zou, Fenghou Yuan, Ali Miserez, Tian Liu, Qing Yang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Formulation of Peptide-Based Nanoparticles Using a Microfluidic Device.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  4. Review
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  13. Review
  14. Review
  15. Review
  16. Review
  17. Toward Artificial Peptide Nanocapsules.Nano-micro letters · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Haopeng Li *School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0009-0008-8945-2180
Xuliang Qian *School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0002-0979-9950
Harini MohanramSchool of Biological Sciences, Division of Structural and Computational Biology, Nanyang Technological University, Singapore, Singapore.
Xiao HanSchool of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.
Huitang QiMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China.
Guijin ZouSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0003-0047-7012
Fenghou YuanMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China.
Ali MiserezSchool of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0003-0864-8170
Tian LiuMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China. tianliu@dlut.edu.cn.ORCID http://orcid.org/0000-0001-9768-5496
Qing YangState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China. qingyang@caas.cn.ORCID http://orcid.org/0000-0001-8623-7532
Huajian GaoSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore. gao.huajian@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-8656-846X
Jing YuSchool of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore. yujing@ntu.edu.sg.ORCID http://orcid.org/0000-0002-4288-951X
Nanyang Technological University · SGDalian University of Technology · CNAgency for Science, Technology and Research · SGAgricultural Genomics Institute at Shenzhen · CN

Funding

Agency for Science, Technology and Research (A*STAR) Start-up Grant (SUG)Ministry of Education - Singapore (MOE) MOE-T2EP30220-0006Ministry of Education - Singapore (MOE) RG138/20, RG135/22Nanyang Technological University (NTU) Start-up Grant (SUG)National Natural Science Foundation of China (National Science Foundation of China) 31871959, 32170502National Research Foundation Singapore (National Research Foundation-Prime Minister's office, Republic of Singapore) NRF-NRFF11-2019-0004
6 · The paper itself

Abstract

Biological systems can create materials with intricate structures and specialized functions. In comparison, precise control of structures in human-made materials has been challenging. Here we report on insect cuticle peptides that spontaneously form nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from the mixing of water and acetone drives the localization and self-assembly of the peptides into hollow nanocapsules. The underlying driving force is found to be the intrinsic affinity of the peptides for a particular solvent concentration, while the diffusion of water and acetone creates a gradient interface that triggers peptide localization and self-assembly. This gradient-mediated self-assembly offers a transformative pathway towards simple generation of drug delivery systems based on peptide nanocapsules.

Indexed as

NanocapsulesPeptidesSolventsAcetoneAnimalsWaterAcetoneNanocapsulesPeptidesSolventsWater

Identifiers

PMID38671050
OpenAlexW4395668939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.