Evidence map›Paper›PMID 38670978›Full record

ArticleScientific reports2024

The mediation effects of nightmares and depression between insomnia and suicidal ideation in young adults.

Zixuan Guo, Xiaoli Han, Tiantian Kong, Yan Wu, Yimin Kang, Yanlong Liu, Fan Wang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  5. The Future of Parasomnias.Journal of sleep research · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zixuan Guo *Medical Neurobiology Lab, Inner Mongolia Medical University, Huhhot, 010110, China.
Xiaoli Han *Clinical Nutrition Department, Friendship Hospital of Urumqi, Urumqi, 830049, China.
Tiantian Kong *Xinjiang Key Laboratory of Neurological Disorder Research, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830063, China.
Yan WuBeijing Hui-Long-Guan Hospital, Peking University, Beijing, 100096, China.
Yimin KangMedical Neurobiology Lab, Inner Mongolia Medical University, Huhhot, 010110, China. kangym@immu.edu.cn.
Yanlong LiuSchool of Mental Health, Wenzhou Medical University, Wenzhou, 325035, China. benjaminlyl@wmu.edu.cn.
Fan WangBeijing Hui-Long-Guan Hospital, Peking University, Beijing, 100096, China. FanWang@bjmu.edu.cn.
Inner Mongolia Medical University · CNXinjiang Medical University · CNBeijing HuiLongGuan Hospital · CNWenzhou Medical University · CN

Funding

National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
Natural Science Foundation of Xinjiang Province 2018D01C228NHLBI NIH HHS R24 HL114473the 10th Inner Mongolia Autonomous Region 'Prairie excellence' Project 2017D01C245the "Qingmiao" program of Beijing Municipal Hospital Management Center QML20212003the Technology Support Project of Xinjiang 2017E0267the Youth Scientific Research Foundation of Beijing HuiLongGuan Hospital LY202106Tianshan Youth Project-Outstanding Youth Science and Technology Talents of Xinjiang 2017Q007
6 · The paper itself

Abstract

Suicide is prevalent among young adults, and epidemiological studies indicate that insomnia, nightmares, and depression are significantly associated with a high incidence of suicidal ideation (SI). However, the causal relationship between these factors and SI remains unclear. Therefore, the purpose of this study was to examine the association between nightmares and depression and insomnia and SI in young adults, as well as to develop a mediation model to investigate the causal relationship between insomnia, nightmare, depression, and SI. We assessed insomnia, nightmares, depression, and SI in 546 young adults using the Insomnia Severity Scale (ISI), Disturbing Dream and Nightmare Severity Scale (DDNSI), Depression Study Scale (CESD-20), and Columbia-Suicide Severity Rating Scale (C-SSRS). Using the Bootstrap method, the mediation effects of nightmares and depression between insomnia and SI were calculated. The results demonstrated that nightmares and depression fully mediated the relationship between insomnia and SI, including the chain-mediation of insomnia and SI between nightmare and depression with an effect value of 0.02, 95% CI 0.01-0.04, and depression as a mediator between insomnia and SI with an effect value of 0.22, 95% CI 0.15-0.29. This study found that depression and nightmares may be risk and predictive factors between insomnia and SI, which implies that the assessment and treatment of depression and the simple or linked effect of nightmares play crucial roles in preventing SI in young adults.

Indexed as

DepressionDreamsSleep Initiation and Maintenance DisordersSuicidal IdeationAdolescentAdultFemaleHumansMaleRisk FactorsYoung AdultDepressionInsomniaMediationNightmareSuicidal ideation

Identifiers

PMID38670978
PMCPMC11052998
OpenAlexW4395667685

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.